ArticleMolecular and cellular biology2006
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 81 citations in OpenAlex.
- Genetic Association ofInternational journal of molecular sciences · 2025Article
- Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs.Biochemical genetics · 2024Article
- Article
- Proprotein Convertases and the Complement System.Frontiers in immunology · 2022Review
- Mouse Models of Human Proprotein Convertase Insufficiency.Endocrine reviews · 2021Review
- Review
- Effect of neurotensin on cultured mouse preimplantation embryos.The Journal of reproduction and development · 2020Article
- FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Spatiotemporal expression of proprotein convertase subtilisin/kexin type 5 in the development of anorectal malformations in fetal rats.Journal of molecular histology · 2017Article
- Thrombin activation of protein C requires prior processing by a liver proprotein convertase.The Journal of biological chemistry · 2017Article
- Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.BMC developmental biology · 2017Article
- Decreased PCSK9 expression in human hepatocellular carcinoma.BMC gastroenterology · 2015Article
- Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.Molecular and cellular biology · 2015Article
- PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?Haematologica · 2015Article
- Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.The Journal of biological chemistry · 2015Article
- PCSK5 mutation in a patient with the VACTERL association.BMC research notes · 2015Article
- Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a).The Journal of biological chemistry · 2013Article
- An integrative genomic analysis of the superior fecundity phenotype in QSi5 mice.Molecular biotechnology · 2013Article
- Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.PloS one · 2013Article
- A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PC5 belongs to the proprotein convertase family and activates precursor proteins by cleavage at basic sites during their transit through the secretory pathway and/or at the cell surface. These precursors include prohormones, proreceptors, growth factors, adhesion molecules, and viral glycoproteins. The Pcsk5 gene encodes two alternatively spliced isoforms, the soluble PC5A and transmembrane PC5B. We have carefully analyzed the expression of PC5 in the mouse during development and in adulthood by in situ hybridization, as well as in mouse tissues and various cell lines by quantitative reverse transcription-PCR. The data show that adrenal cortex and intestine are the richest sources of PC5A and PC5B, respectively. To better define the specific physiological roles of PC5, we have generated a mouse Pcsk5(Delta4)-deficient allele missing exon 4 that encodes the catalytic Asp173. While Delta4/+ heterozygotes were healthy and fertile, genotyping of progeny obtained from Delta4/+ interbreeding indicated that Delta4/Delta4 embryos died between embryonic days 4.5 and 7.5. These data demonstrate that Pcsk5 is an essential gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.