ReviewThe AAPS journal2005
Modeling and simulation of adherence: approaches and applications in therapeutics.
Review in The AAPS journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Temporal Factors and Missed Doses of Tuberculosis Treatment. A Causal Associations Approach to Analyses of Digital Adherence Data.Annals of the American Thoracic Society · 2020Trial
- Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation.Journal of pediatric psychology · 2017Trial
- Measuring adherence by visual inspection of returned empty gel applicators in the CAPRISA 004 microbicide trial.AIDS and behavior · 2014Trial
- An Interactive Pharmacokinetic-Pharmacodynamic Framework to Evaluate Bedaquiline Dose Modifications in Adults With Tuberculosis.CPT: pharmacometrics & systems pharmacology · 2026Article
- Statistical analysis of one-compartment pharmacokinetic models with drug adherence.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?Frontiers in medical technology · 2022Article
- Study protocol for iSIPsmarter: A randomized-controlled trial to evaluate the efficacy, reach, and engagement of a technology-based behavioral intervention to reduce sugary beverages among rural Appalachian adults.Contemporary clinical trials · 2021Article
- Approaches to handling missing or "problematic" pharmacology data: Pharmacokinetics.CPT: pharmacometrics & systems pharmacology · 2021Article
- When Multiple Objective Measures of Medication Adherence Indicate Incongruent Adherence Results: An Example with Pediatric Cancer.International journal of environmental research and public health · 2020Article
- A Systematic Evaluation of Effect of Adherence Patterns on the Sample Size and Power of a Clinical Study.CPT: pharmacometrics & systems pharmacology · 2018Article
- Bayesian population modeling of drug dosing adherence.Journal of pharmacokinetics and pharmacodynamics · 2015Article
- Defining medication adherence in individual patients.Patient preference and adherence · 2015Article
- A model of HIV drug resistance driven by heterogeneities in host immunity and adherence patterns.BMC systems biology · 2013Article
- Quantifying the impact of nonadherence patterns on exposure to oral immunosuppressants.Therapeutics and clinical risk management · 2011Article
- Concepts and challenges in quantitative pharmacology and model-based drug development.The AAPS journal · 2008Article
- Methods to account for inaccuracies in the dosing history when performing population pharmacokinetic analysis.Pharmaceutical research · 2008Article
- Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens.British journal of clinical pharmacology · 2008Article
- An alternative method for population pharmacokinetic data analysis under noncompliance.Journal of pharmacokinetics and pharmacodynamics · 2008Article
- Electronic monitoring of medication adherence in early maintenance phase treatment for pediatric leukemia and lymphoma: identifying patterns of nonadherence.Journal of pediatric psychologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Partial adherence with a prescribed or randomly assigned dose gives rise to unintended variability in actual drug exposure in clinical practice and during clinical trials. There are tremendous costs associated with incomplete and/or improper drug intake-to both individual patients and society as a whole. Methodology for quantifying the relation between adherence, exposure and drug response is an area of active research. Modeling and statistical approaches have been useful in evaluating the impact of adherence on therapeutics and in addressing the challenges of confounding and measurement error which arise in this context. This paper reviews quantitative approaches to using adherence information in improving therapeutics. It draws heavily on applications in the area of HIV pharmacology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.