ArticleJournal of bacteriology2006
Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake transporters: evidence for a novel group of ATP-binding cassette transporters.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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Who cites it
129 citing papers in PubMed, 292 citations in OpenAlex.
- Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Review
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- A periplasmic zinc capture protein enhances the resistance ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Signal-strapping as a protein-sequence search method for the discovery of metalloproteins.Nature communications · 2025Article
- Computational Strategies to Enhance Vitamin BCurrent microbiology · 2025Review
- The type of food influences the behaviour of Listeria monocytogenes in a food-gastrointestinal-infection model.NPJ science of food · 2025Article
- Bacterial association with metals enables in vivo monitoring of urogenital microbiota using magnetic resonance imaging.Communications biology · 2024Article
- Comparative genomic analysis of nickel homeostasis in cable bacteria.BMC genomics · 2024Article
- A flow equilibrium of zinc in cells ofJournal of bacteriology · 2024Article
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- Metagenomic characterization of a novel non-ammonia-oxidizing Thaumarchaeota from hadal sediment.Microbiome · 2024Article
- Metal selectivity and translocation mechanism characterization in proteoliposomes of the transmembrane NiCoT transporter NixA fromChemical science · 2024Article
- Methanogens acquire and bioaccumulate nickel during reductive dissolution of nickelian pyrite.Applied and environmental microbiology · 2023Article
- Functional annotation of uncharacterized proteins from Fusobacterium nucleatum: identification of virulence factors.Genomics & informatics · 2023Article
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- Biosorption and Symbiotic Potential of Horse Gram Rhizobia in Soils Contaminated with Cobalt.Current microbiology · 2023Article
- Functional characterization of the ABC transporters and transposable elements of an uncultured Paracoccus sp. recovered from a hydrocarbon-polluted soil metagenome.Folia microbiologica · 2023Article
- Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transition metals nickel and cobalt, essential components of many enzymes, are taken up by specific transport systems of several different types. We integrated in silico and in vivo methods for the analysis of various protein families containing both nickel and cobalt transport systems in prokaryotes. For functional annotation of genes, we used two comparative genomic approaches: identification of regulatory signals and analysis of the genomic positions of genes encoding candidate nickel/cobalt transporters. The nickel-responsive repressor NikR regulates many nickel uptake systems, though the NikR-binding signal is divergent in various taxonomic groups of bacteria and archaea. B(12) riboswitches regulate most of the candidate cobalt transporters in bacteria. The nickel/cobalt transporter genes are often colocalized with genes for nickel-dependent or coenzyme B(12) biosynthesis enzymes. Nickel/cobalt transporters of different families, including the previously known NiCoT, UreH, and HupE/UreJ families of secondary systems and the NikABCDE ABC-type transporters, showed a mosaic distribution in prokaryotic genomes. In silico analyses identified CbiMNQO and NikMNQO as the most widespread groups of microbial transporters for cobalt and nickel ions. These unusual uptake systems contain an ABC protein (CbiO or NikO) but lack an extracytoplasmic solute-binding protein. Experimental analysis confirmed metal transport activity for three members of this family and demonstrated significant activity for a basic module (CbiMN) of the Salmonella enterica serovar Typhimurium transporter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.