ArticleJournal of bacteriology2006
Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complex.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
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- Comparative Metagenomic Analysis of Bacteriophages and Prophages in Gnotobiotic Mouse Models.Microorganisms · 2024Article
- Phage therapy to treat cystic fibrosisFrontiers in microbiology · 2024Review
- Phage Milagro: a platform for engineering a broad host range virulent phage forJournal of virology · 2023Article
- Synergistic Interactions amongMicrobiology spectrum · 2023Article
- Diversity and potential function of pig gut DNA viruses.Heliyon · 2023Article
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- NOMAD: metagenomic characterisation of the viral pathogen composition in outbreaks of non-malaria acute febrile illness cases.Open research Africa · 2022Article
- Evolutionary genomics of APSE: a tailed phage that lysogenically converts the bacterium Hamiltonella defensa into a heritable protective symbiont of aphids.Virology journal · 2021Article
- Advances in Phage Therapy: Targeting theViruses · 2021Review
- High genomic diversity of novel phages infecting the plant pathogen Ralstonia solanacearum, isolated in Mauritius and Reunion islands.Scientific reports · 2021Article
- Infection Kinetics and Phylogenetic Analysis of vB_EcoD_SU57, a Virulent T1-LikeFrontiers in microbiology · 2020Article
- Comparative Genome Analysis of UropathogenicFrontiers in cellular and infection microbiology · 2019Article
- Complete Genome of theFrontiers in microbiology · 2018Article
- Article
- Impacts of Antibiotic and Bacteriophage Treatments on the Gut-Symbiont-Associated Blissus insularis (Hemiptera: Blissidae).Insects · 2016Article
- Bacteriophage application restores ethanol fermentation characteristics disrupted by Lactobacillus fermentum.Biotechnology for biofuels · 2015Article
- Isolation and Characterization of an Aeromonas punctata Bacteriophage.The open biomedical engineering journal · 2015Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
We have determined the genomic sequences of four virulent myophages, Bcep1, Bcep43, BcepB1A, and Bcep781, whose hosts are soil isolates of the Burkholderia cepacia complex. Despite temporal and spatial separations between initial isolations, three of the phages (Bcep1, Bcep43, and Bcep781, designated the Bcep781 group) exhibit 87% to 99% sequence identity to one another and most coding region differences are due to synonymous nucleotide substitutions, a hallmark of neutral genetic drift. Phage BcepB1A has a very different genome organization but is clearly a mosaic with respect to many of the genes of the Bcep781 group, as is a defective prophage element in Photorhabdus luminescens. Functions were assigned to 27 out of 71 predicted genes of Bcep1 despite extreme sequence divergence. Using a lambda repressor fusion technique, 10 Bcep781-encoded proteins were identified for their ability to support homotypic interactions. While head and tail morphogenesis genes have retained canonical gene order despite extreme sequence divergence, genes involved in DNA metabolism and host lysis are not organized as in other phages. This unusual genome arrangement may contribute to the ability of the Bcep781-like phages to maintain a unified genomic type. However, the Bcep781 group phages can also engage in lateral gene transfer events with otherwise unrelated phages, a process that contributes to the broader-scale genomic mosaicism prevalent among the tailed phages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.