ArticleJournal of bacteriology2006
Genomic changes during chronic Helicobacter pylori infection.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 82 citations in OpenAlex.
- Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.PloS one · 2013Trial
- Genomic characterization of clinical Helicobacter pylori strains from Korea: insights into phylogeny, pan-genome structure, and virulence factors.BMC microbiology · 2026Article
- Correlation versus causation:mSphere · 2026Article
- Foodborne Infections andVaccines · 2024Review
- Influence of genomic variations on glanders serodiagnostic antigens using integrative genomic and transcriptomic approaches.Frontiers in veterinary science · 2023Article
- The high sensitivity and specificity of rapid urease test in diagnosis ofIranian journal of microbiology · 2022Article
- Article
- Trends inMicrobial genomics · 2020Review
- Inference from the analysis of genetic structure of Helicobacter pylori strains isolates from two paediatric patients with recurrent infection.BMC microbiology · 2019Article
- Excision and transfer of an integrating and conjugative element in a bacterial species with high recombination efficiency.Scientific reports · 2019Article
- DifferentialPathogens (Basel, Switzerland) · 2019Article
- Tryptophan usage by Helicobacter pylori differs among strains.Scientific reports · 2019Article
- Persistent Infection and Long-Term Carriage of Typhoidal and Nontyphoidal Salmonellae.Clinical microbiology reviews · 2019Review
- Bacterial 'Grounded' Prophages: Hotspots for Genetic Renovation and Innovation.Frontiers in genetics · 2019Article
- Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori.PloS one · 2018Article
- Lipopolysaccharide modification in Gram-negative bacteria during chronic infection.FEMS microbiology reviews · 2016Review
- Analysis of Genomic Diversity among Helicobacter pylori Strains Isolated from Iranian Children by Pulsed Field Gel Electrophoresis.Iranian journal of pediatrics · 2014Article
- A comprehensive analysis of Helicobacter pylori plasticity zones reveals that they are integrating conjugative elements with intermediate integration specificity.BMC genomics · 2014Article
- Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.Mucosal immunology · 2013Article
- In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori.Infection and immunity · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
The gastric pathogen Helicobacter pylori shows tremendous genetic variability within human populations, both in gene content and at the sequence level. We investigated how this variability arises by comparing the genome content of 21 closely related pairs of isolates taken from the same patient at different time points. The comparisons were performed by hybridization with whole-genome DNA microarrays. All loci where microarrays indicated a genomic change were sequenced to confirm the events. The number of genomic changes was compared to the number of homologous replacement events without loss or gain of genes that we had previously determined by multilocus sequence analysis and mathematical modeling based on the sequence data. Our analysis showed that the great majority of genetic changes were due to homologous recombination, with 1/650 events leading to a net gain or loss of genes. These results suggest that adaptation of H. pylori to the host individual may principally occur through sequence changes rather than loss or gain of genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.