ArticleJournal of bacteriology2006
Evidence for clonal evolution among highly polymorphic genes in methicillin-resistant Staphylococcus aureus.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
- Community-Acquired Methicillin-ResistantDiagnostics (Basel, Switzerland) · 2023Article
- Molecular and Source-Specific Profiling of HospitalMicroorganisms · 2023Article
- Core genes can have higher recombination rates than accessory genes within global microbial populations.eLife · 2022Article
- Phylogeographical Analysis Reveals the Historic Origin, Emergence, and Evolutionary Dynamics of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Distribution of the Most PrevalentFrontiers in microbiology · 2018Review
- The recombination dynamics of Staphylococcus aureus inferred from spA gene.BMC microbiology · 2016Article
- Biogeography and evolution of Thermococcus isolates from hydrothermal vent systems of the Pacific.Frontiers in microbiology · 2015Article
- Multiple-strain colonization in nasal carriers of Staphylococcus aureus.Journal of clinical microbiology · 2014Article
- Insights into alpha-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin.PloS one · 2014Article
- Article
- Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).FEMS immunology and medical microbiology · 2012Review
- The impact of recombination on dN/dS within recently emerged bacterial clones.PLoS pathogens · 2011Article
- Evolutionary analyses of Staphylococcus aureus identify genetic relationships between nasal carriage and clinical isolates.PloS one · 2011Article
- GenHtr: a tool for comparative assessment of genetic heterogeneity in microbial genomes generated by massive short-read sequencing.BMC bioinformatics · 2010Article
- Fibronectin-binding protein B variation in Staphylococcus aureus.BMC microbiology · 2010Article
- Natural variability of in vitro adherence to fibrinogen and fibronectin does not correlate with in vivo infectivity of Staphylococcus aureus.Infection and immunity · 2010Article
- Regional profiling for determination of genotype diversity of mastitis-specific Staphylococcus aureus lineage in Canada by use of clumping factor A, pulsed-field gel electrophoresis, and spa typing.Journal of clinical microbiology · 2010Article
- Staphylococcus aureus nasal carriage and its contributing factors.Future microbiology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of Staphylococcus aureus has been described as predominantly clonal, based on evidence from seven housekeeping genes. We aimed to test if this was also true for more polymorphic genes. In a collection of 60 isolates including major European epidemic methicillin-resistant S. aureus (MRSA) and sporadic MRSA strains, we compared the partial gene sequences of seven housekeeping genes (arcC, aroE, glpF, gmk, pta, tpi, and yqiL), six core adhesion genes (present in all strains) (clfA, clfB, fnbA, map, sdrC, and spa), and four accessory adhesion genes (not present in all strains) (ebpS, fnbB, sdrD, and sdrE). Nucleotide diversity of adhesion genes was 2- to 10-fold higher than genes used for multilocus sequence typing. All genes showed evidence for purifying selection with a weakly reduced level among accessory adhesion genes. Among these highly variable genes, there was no evidence for a difference in molecular evolution between epidemic and sporadic strains. Gene trees constructed from concatenated sequences of housekeeping, core adhesion, and accessory adhesion genes were highly congruent, indicating clonality, despite some evidence for homologous exchange. Further evidence for clonality was found with an overall positive correlation of allelic and nucleotidic divergence for both seven housekeeping genes and six core adhesion genes. However, for small allelic differences that fit the demarcations of clonal complexes (CCs) there was no such correlation, suggesting that recombination occurred. Therefore, despite an overall clonal population structure, recombination between related isolates within CCs might have contributed to S. aureus evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.