Evidence map›Paper›PMID 16352764›Full record

ReviewProceedings of the American Thoracic Society2005

Molecular imaging of pulmonary gene expression with positron emission tomography.

Sekhar Dharmarajan, Daniel P Schuster

Open access · greenAbstract readReview
In one paragraph

Review in Proceedings of the American Thoracic Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Two-photon microscopy in pulmonary research.Seminars in immunopathology · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sekhar DharmarajanDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Daniel P Schuster
Washington University in St. Louis · US

Funding

Pulmonary Transgene Expression Imaging with PETR01HL076488 · NHLBI · WASHINGTON UNIVERSITY · PI ROGERS, BUCK E. · 2005 to 2008
$1.8M
Neutrophil Specific Transgene Expression ImagingR21EB004732 · NIBIB · WASHINGTON UNIVERSITY · PI SCHUSTER, DANIEL P · 2004 to 2004
$176k
Regulation of Apoptosis in Lung TransplantationF32HL074687 · NHLBI · WASHINGTON UNIVERSITY · PI DHARMARAJAN, SEKHAR · 2003 to 2004
$94k
NHLBI NIH HHS F32 HL074687NHLBI NIH HHS R01HL076488NIBIB NIH HHS R21EB04732
6 · The paper itself

Abstract

Gene expression imaging is one form of molecular imaging used to visualize, characterize, and quantify, spatially and temporally, normal as well as pathologic processes at cellular and subcellular levels within intact living organisms. Most studies to date have employed positron emission tomography as the imaging platform to detect, monitor, and quantify gene expression in the lungs. These studies have shown that imaging can be used to determine the onset and duration of transgene expression, the effectiveness of different gene delivery systems, and the linearity of vector dose-response relationships. This rapidly developing field can be expected to provide useful new tools with which to study gene expression in transgenic animals and in humans during gene therapy.

Indexed as

Positron-Emission TomographyAnimalsGene ExpressionGenes, ReporterHumansLungMiceProteinsRatsTransgenesProteins

Identifiers

PMID16352764
PMCPMC2713344
OpenAlexW2021361385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.