ArticleProceedings of the National Academy of Sciences of the United States of America2005
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
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Who cites it
145 citing papers in PubMed.
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- GADMA: Genetic algorithm for inferring demographic history of multiple populations from allele frequency spectrum data.GigaScience · 2020Article
- The Evolutionary History of Human Skin Pigmentation.Journal of molecular evolution · 2020Review
- Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.BMC evolutionary biology · 2019Article
- The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East.Current biology : CB · 2019Article
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- Population genetic evidence for positive and purifying selection acting at the human IFN-γ locus in Africa.Genes and immunity · 2019Article
- Genes from the TAS1R and TAS2R Families of Taste Receptors: Looking for Signatures of Their Adaptive Role in Human Evolution.Genome biology and evolution · 2018Article
- How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data.Genetics and molecular biology · 2018Article
- The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.Current opinion in genetics & development · 2016Review
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- Determining the Effect of Natural Selection on Linked Neutral Divergence across Species.PLoS genetics · 2016Article
- Early farmers from across Europe directly descended from Neolithic Aegeans.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
85 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
We present an expanded data set of 50 unlinked autosomal noncoding regions, resequenced in samples of Hausa from Cameroon, Italians, and Chinese. We use these data to make inferences about human demographic history by using a technique that combines multiple aspects of genetic data, including levels of polymorphism, the allele frequency spectrum, and linkage disequilibrium. We explore an extensive range of demographic parameters and demonstrate that our method of combining multiple aspects of the data results in a significant reduction of the compatible parameter space. In agreement with previous reports, we find that the Hausa data are compatible with demographic equilibrium as well as a set of recent population expansion models. In contrast to the Hausa, when multiple aspects of the data are considered jointly, the non-Africans depart from an equilibrium model of constant population size and are compatible with a range of simple bottleneck models, including a 50-90% reduction in effective population size occurring some time after the appearance of modern humans in Africa 160,000-120,000 years ago.
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