ArticleProceedings of the National Academy of Sciences of the United States of America2005
Two types of precursor cells in a multipotential hematopoietic cell line.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
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- Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells.Cancers · 2022Review
- A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation.Blood advances · 2021Article
- Genetic fingerprint defines hematopoietic stem cell pool size and function.Haematologica · 2020Article
- Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.Haematologica · 2020Article
- An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors.Nucleic acids research · 2017Article
- Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro.Journal of diabetes research · 2017Article
- Identification of key factors regulating self-renewal and differentiation in EML hematopoietic precursor cells by RNA-sequencing analysis.Journal of visualized experiments : JoVE · 2014Article
- Dynamic equilibrium of heterogeneous and interconvertible multipotent hematopoietic cell subsets.Scientific reports · 2014Article
- A CO-FISH assay to assess sister chromatid segregation patterns in mitosis of mouse embryonic stem cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
- The role of tumor suppressor p15Ink4b in the regulation of hematopoietic progenitor cell fate.Blood cancer journal · 2013Article
- Inferring rules of lineage commitment in haematopoiesis.Nature cell biology · 2012Article
- Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line.PLoS genetics · 2012Article
- YBX1 expression and function in early hematopoiesis and leukemic cells.Immunogenetics · 2011Article
- Complex interactions in EML cell stimulation by stem cell factor and IL-3.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Inactivation of a single copy of Crebbp selectively alters pre-mRNA processing in mouse hematopoietic stem cells.PloS one · 2011Article
- Modeling the clonal heterogeneity of stem cells.Theoretical biology & medical modelling · 2010Article
- Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice.The Journal of clinical investigation · 2006Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The biochemistry of early stages of hematopoietic differentiation is difficult to study because only relatively small numbers of precursor cells are available. The murine EML cell line is a multipotential cell line that can be used to model some of these steps. We found that the lineage- EML precursor cells can be separated into two populations based on cell surface markers including CD34. Both populations contain similar levels of stem cell factor (SCF) receptor (c-Kit) but only the CD34+ population shows a growth response when treated with SCF. Conversely, the CD34- population will grow in the presence of the cytokine IL-3. The human beta-globin locus control region hypersensitive site 2 plays different roles on beta-globin transcription in the CD34+ and CD34- populations. The two populations are present in about equal amounts in culture, and the CD34+ population rapidly regenerates the mixed population when grown in the presence of SCF. We suggest that this system may mimic a normal developmental transition in hematopoiesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.