ArticleJournal of virology2006
Characterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Integrative structural interactomics reveals protein organization and structure in a giant virus.Nature communications · 2026Article
- Coevolutionary and Phylogenetic Analysis of Mimiviral Replication Machinery Suggest the Cellular Origin of Mimiviruses.Molecular biology and evolution · 2021Article
- A highly processive actinobacterial topoisomerase I - thoughts onMicrobiology (Reading, England) · 2020Review
- Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB.Biochemistry · 2017Article
- Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.Scientific reports · 2017Article
- topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB.Nucleic acids research · 2016Article
- Mimivirus collagen is modified by bifunctional lysyl hydroxylase and glycosyltransferase enzyme.The Journal of biological chemistry · 2011Article
- Giant virus with a remarkable complement of genes infects marine zooplankton.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site.Structure (London, England : 1993) · 2010Article
- Insights from the structure of a smallpox virus topoisomerase-DNA transition state mimic.Structure (London, England : 1993) · 2010Article
- Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity.Biology direct · 2009Article
- The polyadenylation site of Mimivirus transcripts obeys a stringent 'hairpin rule'.Genome research · 2009Article
- Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms.Nucleic acids research · 2009Review
- A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya.Biology direct · 2008Article
- Phylogenetic evidence for extensive lateral acquisition of cellular genes by Nucleocytoplasmic large DNA viruses.BMC evolutionary biology · 2008Article
- Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.The Journal of biological chemistry · 2008Article
- Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes.Virology · 2007Article
- Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products.Journal of virology · 2006Article
- The nucleoside diphosphate kinase from mimivirus: a peculiar affinity for deoxypyrimidine nucleotides.Journal of bioenergetics and biomembranes · 2006Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Mimivirus, a parasite of Acanthamoeba polyphaga, is the largest DNA virus known; it encodes dozens of proteins with imputed functions in nucleic acid transactions. Here we produced, purified, and characterized mimivirus DNA topoisomerase IB (TopIB), which we find to be a structural and functional homolog of poxvirus TopIB and the poxvirus-like topoisomerases discovered recently in bacteria. Arginine, histidine, and tyrosine side chains responsible for TopIB transesterification are conserved and essential in mimivirus TopIB. Moreover, mimivirus TopIB is capable of incising duplex DNA at the 5'-CCCTT cleavage site recognized by all poxvirus topoisomerases. Based on the available data, mimivirus TopIB appears functionally more akin to poxvirus TopIB than bacterial TopIB, despite its greater primary structure similarity to the bacterial TopIB group. We speculate that the ancestral bacterial/viral TopIB was disseminated by horizontal gene transfer within amoebae, which are permissive hosts for either intracellular growth or persistence of many present-day bacterial species that have a type IB topoisomerase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.