ArticleJournal of virology2006
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Review
- SLAMF7 (CD319) on activated CD8Cell death and differentiation · 2025Article
- Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.Endocrine reviews · 2019Review
- Tipping the balance: inhibitory checkpoints in intestinal homeostasis.Mucosal immunology · 2019Review
- Characterization of CTLA4 Trafficking and Implications for Its Function.Biophysical journal · 2018Article
- Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.Clinical and experimental immunology · 2017Review
- Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.Nature medicine · 2017Article
- Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.Blood · 2017Article
- Review
- T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance.Cell death & disease · 2015Review
- A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Confusing signals: recent progress in CTLA-4 biology.Trends in immunology · 2015Review
- Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.Nature medicine · 2014Article
- Treg and CTLA-4: two intertwining pathways to immune tolerance.Journal of autoimmunity · 2013Review
- High efficiency of antiviral CD4(+) killer T cells.PloS one · 2013Article
- Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity.Journal of virology · 2012Article
- The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.Nature reviews. Immunology · 2011Article
- Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.Science (New York, N.Y.) · 2011Article
- Immunosuppressive mechanisms during viral infectious diseases.Methods in molecular biology (Clifton, N.J.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
CTLA-4 is considered one of the most potent negative regulators of T-cell activation. To circumvent experimental limitations due to fatal lymphoproliferative disease associated with genetic ablation of CTLA-4, we have used radiation chimeras reconstituted with a mixture of CTLA-4+/+ and CTLA-4-/- bone marrow that retain a normal phenotype and allow the evaluation of long-term T-cell immunity under conditions of intrinsic CTLA-4 deficiency. Following virus infection, we profiled primary, memory, and secondary CD8+ and CD4+ T-cell responses directed against eight different viral epitopes. Our data demonstrate unaltered antigen-driven proliferation, acquisition of effector functions, distribution of epitope hierarchies, T-cell receptor repertoire selection, functional avidities, and long-term memory maintenance in the absence of CTLA-4. Moreover, regulation of memory T-cell survival and homeostatic proliferation, as well as secondary responses, was equivalent in virus-specific CTLA4+/+ and CTL-A-4-/- T-cell populations. Thus, lack of CTLA-4 expression by antigen-specific T cells can be compensated for by extrinsic factors in the presence of CTLA-4 expression by other cells. These findings have implications for the physiologic, pathological, and therapeutic regulation of costimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.