ArticleThe British journal of nutrition2005
Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep.
Article in The British journal of nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Maternal nutrition and its intergenerational links to non-communicable disease metabolic risk factors: a systematic review and narrative synthesis.Journal of health, population, and nutrition · 2021Pooled it
- Long-Term Impact of the Great Chinese Famine on the Risks of Specific Arrhythmias and Severe Hypertension in the Offspring at an Early Stage of Aging.Journal of personalized medicine · 2023Article
- Animal Foetal Models of Obesity and Diabetes - From Laboratory to Clinical Settings.Frontiers in endocrinology · 2022Review
- Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development.Frontiers in physiology · 2021Review
- Article
- Chronic hypoxia in pregnancy affected vascular tone of renal interlobar arteries in the offspring.Scientific reports · 2015Article
- Nephron number and its determinants in early life: a primer.Pediatric nephrology (Berlin, Germany) · 2014Review
- Identification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity.Physiological genomics · 2013Article
- Consumption habits of pregnant women and implications for developmental biology: a survey of predominantly Hispanic women in California.Nutrition journal · 2013Article
- Maternal high-fat diet impacts endothelial function in nonhuman primate offspring.International journal of obesity (2005) · 2013Article
- Impaired hypothalamic mTOR activation in the adult rat offspring born to mothers fed a low-protein diet.PloS one · 2013Article
- A common cause for a common phenotype: the gatekeeper hypothesis in fetal programming.Medical hypotheses · 2012Article
- Differential effects of clinical doses of antenatal betamethasone on nephron endowment and glomerular filtration rate in adult sheep.Reproductive sciences (Thousand Oaks, Calif.) · 2010Article
- Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring.American journal of physiology. Renal physiology · 2009Article
- Nutritional programming of the metabolic syndrome.Nature reviews. Endocrinology · 2009Review
- Nutritional programming of disease: unravelling the mechanism.Journal of anatomy · 2009Review
- Effect of maternal nutrient restriction from early to midgestation on cardiac function and metabolism after adolescent-onset obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- The effect of fetal and neonatal nicotine exposure on renal development of AT(1) and AT(2) receptors.Reproductive toxicology (Elmsford, N.Y.) · 2009Article
- Perinatal taurine alters arterial pressure control and renal function in adult offspring.Advances in experimental medicine and biology · 2009Article
- Pregnancy and perinatal outcomes after assisted reproduction: a comparative study.Irish journal of medical science · 2008Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The prenatal diet can program an individual's cardiovascular system towards later higher resting blood pressure and kidney dysfunction, but the extent to which these programmed responses are directly determined by the timing of maternal nutritional manipulation is unknown. In the present study we examined whether maternal nutrient restriction targeted over the period of maximal placental growth, i.e. days 28-80 of gestation, resulted in altered blood pressure or kidney development in the juvenile offspring. This was undertaken in 6-month-old sheep born to mothers fed control (100-150 % of the recommended metabolisable energy (ME) intake for that stage of gestation) or nutrient-restricted (NR; 50 % ME; n 6) diets between days 28 and 80 of gestation. Controls were additionally grouped according to normal (>3, n 7) or low body condition score (LBCS; <2, n 6), thereby enabling us to examine the effect of maternal body composition on later cardiovascular function. From day 80 to term (approximately 147 d) all sheep were fed to 100 % ME. Offspring were weaned at 12 weeks and pasture-reared until 6 months of age when cardiovascular function was determined. Both LBCS and NR sheep tended to have lower resting systolic (control, 85 (se 2); LBCS, 77 (se 3); NR, 77 (se 3) mmHg) and diastolic blood pressure relative to controls. Total nephron count was markedly lower in both LBCS and NR relative to controls (LBCS, 59 (se 6); NR, 56 (se 12) %). Our data suggest that maternal body composition around conception is as important as the level of nutrient intake during early pregnancy in programming later cardiovascular health.
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