ArticleParasitology research2006
Giardia lamblia behavior under cytochalasins treatment.
Article in Parasitology research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- The cytoskeleton of pathogenic protists.Bioscience reports · 2026Review
- Ultrastructural Alterations of the Human PathogenPathogens (Basel, Switzerland) · 2023Review
- Unusual Cell Structures and Organelles inMicroorganisms · 2022Review
- Nek8445, a protein kinase required for microtubule regulation and cytokinesis inMolecular biology of the cell · 2020Article
- A new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in vitro.Parasitology research · 2016Article
- Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites.Parasitology research · 2013Article
- Giardia flagellar motility is not directly required to maintain attachment to surfaces.PLoS pathogens · 2011Article
- An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.Journal of lipid research · 2010Article
- Rab11 and actin cytoskeleton participate in Giardia lamblia encystation, guiding the specific vesicles to the cyst wall.PLoS neglected tropical diseases · 2010Article
- Article
- Tonic shock induces detachment of Giardia lamblia.PLoS neglected tropical diseases · 2008Article
- A sphingolipid inhibitor induces a cytokinesis arrest and blocks stage differentiation in Giardia lamblia.Antimicrobial agents and chemotherapy · 2008Article
- Clathrin-dependent pathways and the cytoskeleton network are involved in ceramide endocytosis by a parasitic protozoan, Giardia lamblia.International journal for parasitology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giardia lamblia, a flagellated protist, is the parasite most commonly found in the intestinal tract of humans and other mammals causing a disease known as giardiasis. This parasite presents several cytoskeletal structures whose major components are microtubules, namely: the ventral adhesive disk, eight flagella axonemes, the median body, and funis. However, the cytoskeletal filamentous structures are poorly understood, and therefore, less studied. In the present work, we used actin-interacting drugs such as cytochalasin B and D to investigate their effects on Giardia ultrastructure. Axenically grown G. lamblia trophozoites were treated with these drugs and analyzed by fluorescence microscopy and scanning and transmission electron microscopy. It was observed that trophozoites became completely misshapen, detached from the glass surface, and failed to complete cell division. The main alterations observed included: (1) disk fragmentation, (2) presence of large vacuoles, (3) alterations in flagella number and flagella internalization, (4) blocked cytokinesis but not the karyokinesis, and (5) presence of membrane undulations and blebs. These findings are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.