ArticleSpinal cord2006
Use of c-fos to identify activity-dependent spinal neurons after stepping in intact adult rats.
Article in Spinal cord, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Preoperative Esketamine Alleviates Postoperative Pain after Endoscopic Plasma Adenotonsillectomy in Children.Clinical medicine & research · 2023Trial
- Oxycodone preemptive analgesia after endoscopic plasma total adenotonsillectomy in children: A randomized controlled trial.Medicine · 2020Trial
- Chronic exercise reduces astrocytic c-Fos and CCL2 via conditioned serum and cerebrospinal fluid.Narra J · 2025Article
- Neuropathic Pain-Like Responses in a Chronic CNS Injury Model Are Mediated by Corticospinal-Targeted Spinal Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Widespread neuronal activity related to bimanual coordination in non-human primates: evidence from Fos-like activation during bimanual versus unimanual motor task.Neuroscience insights · 2025Article
- Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.Cell reports · 2024Article
- Activation of the spinal and brainstem locomotor networks during free treadmill stepping in rats lacking dopamine transporter.Frontiers in molecular neuroscience · 2023Article
- Intermediate gray matter interneurons in the lumbar spinal cord play a critical and necessary role in coordinated locomotion.PloS one · 2023Article
- Rostrocaudal Distribution of the C-Fos-Immunopositive Spinal Network Defined by Muscle Activity during Locomotion.Brain sciences · 2021Article
- A model for the transfer of control from the brain to the spinal cord through synaptic learning.Journal of computational neuroscience · 2020Article
- Redundancy and multifunctionality among spinal locomotor networks.Journal of neurophysiology · 2020Article
- TRPM8-mediated cutaneous stimulation modulates motor neuron activity during treadmill stepping in mice.The journal of physiological sciences : JPS · 2019Article
- Distribution of Spinal Neuronal Networks Controlling Forward and Backward Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Effect of subcutaneous treatment with human umbilical cord blood-derived multipotent stem cells on peripheral neuropathic pain in rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: A focus on lamina X.Brain research · 2016Article
- Spinal neuronal activation during locomotor-like activity enabled by epidural stimulation and 5-hydroxytryptamine agonists in spinal rats.Journal of neuroscience research · 2015Article
- Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition.Molecular brain · 2014Article
- Axon regeneration and exercise-dependent plasticity after spinal cord injury.Annals of the New York Academy of Sciences · 2013Review
- Peripheral nerve grafts after cervical spinal cord injury in adult cats.Experimental neurology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
designAn investigation of c-fos activation pattern in spinal neurons of intact adult rats after acute bouts of treadmill locomotion.
objectivesTo map spinal neurons that are involved in quadrupedal treadmill stepping of intact adult rats by using c-fos as a marker. SETTINGS: Los Angeles, CA, USA.
methodsSpinal cord sections of rats that were not stepped (n = 4) were used to map the FOS-positive (+) neurons under basal conditions. The stepped group (n = 16) was placed on a treadmill to step quadrupedally for varying durations to induce c-fos activity. Spinal cord sections of thoracic and lumbar segments of Stp and Nstp rats were processed using a c-fos antibody, choline acetyl transferase and heat shock protein 27 for identifying motoneurons.
resultsStepping induced a greater number of FOS+ neurons than was observed in rats that did not step on the treadmill. There was a rostrocaudal and a dorsoventral gradient of FOS labeled neurons. The number of FOS+ neurons increased with the duration of treadmill stepping. Significant increases in FOS+ neurons were in the most medial parts of laminae IV, V, and VII. FOS+ motoneurons increased with treadmill stepping, particularly in large motoneurons (> or = 700 microm2).
conclusionThese data suggest that FOS can be used to identify activity-dependent neuronal pathways in the spinal cord that are associated with treadmill stepping, specifically in lamina VII and in alpha motoneurons. SPONSORSHIP: NIH NS16333, NS40917, and the Christopher Reeve Paralysis Foundation (CRPF VEC 2002).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.