ArticleThe Journal of cell biology2005
Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- The tubulin database: Linking mutations, modifications, ligands and local interactions.PloS one · 2023Article
- Polarity in Ciliate Models: From Cilia to Cell Architecture.Frontiers in cell and developmental biology · 2019Review
- Tetrahymena basal bodies.Cilia · 2015Review
- Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ.PloS one · 2015Article
- GTP regulates the microtubule nucleation activity of γ-tubulin.Nature cell biology · 2013Article
- ε-tubulin is essential in Tetrahymena thermophila for the assembly and stability of basal bodies.Journal of cell science · 2013Article
- Sfr13, a member of a large family of asymmetrically localized Sfi1-repeat proteins, is important for basal body separation and stability in Tetrahymena thermophila.Journal of cell science · 2013Article
- Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.Cellular and molecular life sciences : CMLS · 2013Review
- Distinct functional roles of β-tubulin isotypes in microtubule arrays of Tetrahymena thermophila, a model single-celled organism.PloS one · 2012Article
- The two domains of centrin have distinct basal body functions in Tetrahymena.Molecular biology of the cell · 2011Article
- Building the centriole.Current biology : CB · 2010Review
- Centrioles: active players or passengers during mitosis?Cellular and molecular life sciences : CMLS · 2010Review
- Basal body stability and ciliogenesis requires the conserved component Poc1.The Journal of cell biology · 2009Article
- Basal body assembly in ciliates: the power of numbers.Traffic (Copenhagen, Denmark) · 2009Review
- Basal body components exhibit differential protein dynamics during nascent basal body assembly.Molecular biology of the cell · 2009Article
- Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication.Genetics · 2008Article
- What do genic mutations tell us about the structural patterning of a complex single-celled organism?Eukaryotic cell · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have used in vitro mutagenesis and gene replacement to study the function of the nucleotide-binding domain (NBD) of gamma-tubulin in Tetrahymena thermophila. In this study, we show that the NBD has an essential function and that point mutations in two conserved residues lead to over-production and mislocalization of basal body (BB) assembly. These results, coupled with previous studies (Dammermann, A., T. Muller-Reichert, L. Pelletier, B. Habermann, A. Desai, and K. Oegema. 2004. Dev. Cell. 7:815-829; La Terra, S., C.N. English, P. Hergert, B.F. McEwen, G. Sluder, and A. Khodjakov. 2005. J. Cell Biol. 168:713-722), suggest that to achieve the precise temporal and spatial regulation of BB/centriole assembly, the initiation activity of gamma-tubulin is normally suppressed by a negative regulatory mechanism that acts through its NBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.