Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Incremental prognostic value of combined perfusion and function assessment during myocardial gated SPECT in patients aged 75 years or older.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic and prognostic significance of transient ischemic dilation (TID) in myocardial perfusion imaging: A systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Pooled it
- Myocarditis in the Modern Era: Navigating Diagnosis, Innovative Treatments, the COVID-19 Challenge and the Role of Artificial Intelligence.Cardiology research and practice · 2026Review
- Transient ischemic dilation ratio by [The international journal of cardiovascular imaging · 2025Article
- Preoperative nuclear stress testing in the very old patient population.World journal of cardiology · 2020Article
- Prediction of 14-year cardiovascular outcomes by dobutamine stressJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Stress myocardial perfusion imaging in the elderly.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Long-term prognostic implications of myocardial perfusion imaging in octogenarians: an all-comer, cohort study.European journal of nuclear medicine and molecular imaging · 2017Article
- Value of Exercise ECG for Risk Stratification in Suspected or Known CAD in the Era of Advanced Imaging Technologies.JACC. Cardiovascular imaging · 2015Review
- Article
- Predictive value of exercise myocardial perfusion imaging in the Medicare population: the impact of the ability to exercise.Cardiovascular diagnosis and therapy · 2014Article
- Prognostic role of myocardial single photon emission computed tomography in the elderly.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Does myocardial perfusion imaging provide incremental prognostic information to left ventricular ejection fraction?Current cardiology reports · 2010Review
- The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene.European journal of nuclear medicine and molecular imaging · 2007Review
- Nuclear stress testing in elderly patients: a review of its use in the assessment of cardiac risk, particularly in patients undergoing preoperative risk assessment.Drugs & aging · 2007Review
- American Society of Nuclear Cardiology review of the ACCF/ASNC appropriateness criteria for single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI).Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerfusion and functional data obtained during gated single photon emission computed tomography (SPECT) have proven prognostic value in the middle-aged patient population. The aim of this study was to investigate whether perfusion and functional cardiac gated SPECT data have prognostic value in patients aged 75 years or older. METHODS AND
resultsWe studied clinical and gated SPECT predictors of cardiac and all-cause death in 294 patients aged 75 years or older with known or suspected coronary artery disease who were referred for tetrofosmin cardiac gated SPECT imaging. Summed perfusion scores were calculated in a 17-segment model by use of commercially available software (4D-MSPECT). Left ventricular functional data were calculated by use of QGS gated SPECT software. The median age of the study population was 78 years (range, 75-91 years). There were 160 men (54%) and 134 women (46%). During a median follow-up of 25.9 months (range, 1.8-36 months), 47 patients (16%) died (27 cardiac deaths). In a multivariate Cox proportional hazards regression analysis, the summed rest score (chi2 gain = 8.0, P = .009), transient ischemic dilatation index (chi2 gain = 6.3, P = .012), and resting left ventricular ejection fraction (chi2 gain = 7.0, P = .030) were independent predictors of all-cause death. The summed rest score (chi2 gain = 8.2, P = .004) and resting end-systolic volume (chi2 gain = 13.7, P = .005) were independent predictors of cardiac death.
conclusionsThis study showed that gated SPECT left ventricular functional data assessed during myocardial gated SPECT provide independent and incremental information above clinical and perfusion SPECT data for the prediction of cardiac and all-cause death in patients aged 75 years or older referred for myocardial SPECT imaging.
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