ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2006
Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals.Nature communications · 2026Article
- Three-dimensional structure and epithelial changes of the piriform sinus fistula in cotton rats.Cell and tissue research · 2026Article
- Medullary Thyroid Carcinoma Without Calcitonin: A Case Linking Ultimobranchial Bodies to Tumor Evolution.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Thyroid C-Cell Biology and Oncogenic Transformation.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Cribriform morular thyroid carcinoma: a case report with pathological, immunohistochemical, and molecular findings suggesting an origin from follicular cells (or their endodermal precursors).Virchows Archiv : an international journal of pathology · 2023Article
- C-cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat.Veterinary medicine and science · 2023Article
- Developmental basis of evolutionary lung loss in plethodontid salamanders.Science advances · 2022Article
- Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds.Cells · 2021Article
- Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies.Cellular and molecular neurobiology · 2021Review
- Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited.European thyroid journal · 2016Review
- Thyreoglossal Duct Cyst with Evidence of Solid Cell Nests and Atypical Thyroid Follicles.Endocrine pathology · 2016Article
- Review
- Revising the embryonic origin of thyroid C cells in mice and humans.Development (Cambridge, England) · 2015Article
- Thyroid C-Cell Biology and Oncogenic Transformation.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2015Review
- Thyroid regeneration: how stem cells play a role?Frontiers in endocrinology · 2014Review
- Stem cell antigen 1-positive mesenchymal cells are the origin of follicular cells during thyroid regeneration.PloS one · 2013Article
- Thyroid regeneration: characterization of clear cells after partial thyroidectomy.Endocrinology · 2012Article
- In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.BMC developmental biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The ultimobranchial body (UBB) is an outpocketing of the fourth pharyngeal pouch that fuses with the thyroid diverticulum, giving rise to calcitonin-producing C-cells. In this study, we demonstrate that the UBB is composed of two types of cells: one expressing T/ebp/Nkx2.1 and the other expressing p63. The former cell type, accounting for a majority of the UBB, requires T/ebp/Nkx2.1 for their survival. In contrast, the p63-positive cells, even in the absence of T/ebp/Nkx2.1 expression, can proliferate and give rise to a vesicular structure that is lined by a monolayer of p63-negative cells, surrounded by a cluster and/or single layer of p63-positive cells, displaying the basal/stem cell phenotype. T/ebp/Nkx2.1 haploinsufficiency causes abnormal fusion of the UBB with the thyroid diverticulum, which stays as a cluster of C-cells around the vesicular structure, similar to the one observed in mice null for T/ebp/Nkx2.1 expression. These results demonstrate that T/ebp/Nkx2.1 plays a role in the survival of UBB cells, their dissemination into the thyroid diverticulum, and the formation of UBB-derived vesicular structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.