ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2006
Prospective study of the long term change of the oral flora after radiation therapy.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Oral microbiota in head and neck cancer patients during radiotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- A systematic review of dental disease management in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- A systematic review of dental disease in patients undergoing cancer therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010Pooled it
- Article
- Oral microbiome alterations after cancer treatment: a scoping review and analysis.Medical oncology (Northwood, London, England) · 2025Article
- An increase in Fusobacterium is associated with the severity of oral mucositis after radiotherapy.Scientific reports · 2025Article
- Frequency of periodontal disease in head and neck cancer patients after radiation therapy: a cross-sectional study.BMC oral health · 2025Article
- Influence of irradiated dentin, biofilm and different artificial saliva formulations on root dentin demineralization.Heliyon · 2024Article
- In vitro effect of TiF4/NaF solution on the development of radiation-induced dentin caries.Journal of applied oral science : revista FOB · 2024Article
- Evaluation of Alteration in Oral Microbial Flora Pre- and Postradiation Therapy in Patients with Head and Neck Cancer.Journal of pharmacy & bioallied sciences · 2020Article
- Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians.Medicina oral, patologia oral y cirugia bucal · 2018Review
- Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis.Cancer medicine · 2017Review
- Investigation of salivary function and oral microbiota of radiation caries-free people with nasopharyngeal carcinoma.PloS one · 2015Article
- Tensile Bond Strengths of Two Adhesives on Irradiated and Nonirradiated Human Dentin.BioMed research international · 2015Article
- Fermentation of sugars and sugar alcohols by plaque Lactobacillus strains.Clinical oral investigations · 2013Article
- Ecology of lactobacilli in the oral cavity: a review of literature.The open microbiology journal · 2008Article
- aMMP-8 and MMP-9: Potential Biomarkers for periodontitis Progression in Patients Receiving Radiotherapy for Head and Neck Carcinoma.Cancer control : journal of the Moffitt Cancer CenterArticle
- Oral microbial profile in oral cancer patients before and after radiation therapy in a cancer care center - A prospective study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this prospective study was to evaluate the long term change in oral pathogens following radiation therapy.
methodsTwenty-two patients with planned radiation therapy (>30 Gy) of head and neck squamous cell carcinoma were included. Before radiation therapy, after 3, 6, and 12 months samples from the deepest periodontal pocket were drawn. Five major periodontal pathogens were studied using DNA probes (Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Bacteriodes forsythus, Treponema denticola). Stimulated saliva was sampled for the microbiologic study of caries pathogens (streptococci and lactobacilli). Plaque index and decayed, missing, filled tooth surfaces (DMF-S) were recorded.
resultsA normalisation of the caries bacteria is not found correlating to a significant increase in the number of affected teeth (DMF-S) from 80.7 to 88.5 after 12 months. The plaque index remained unchanged. The incidence of periodontal pathogens did not significantly change during the follow up.
conclusionIn contrast to radiation caries there seems to be no microbiological evidence for "radiation periodontitis". Despite of the intensive oral hygiene no reduction of the high number of caries pathogens is found, which leads to a high risk of tooth decay even 12 months after radiation.
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