ArticleThe Journal of clinical investigation2006
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
Article in The Journal of clinical investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01210521 (Use of Vitamin D3 for the Treatment of Steroid Resistant Asthmatic Patients), which is not on this map. Cited by 202 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Vitamin D3 for the Treatment of Steroid Resistant Asthmatic Patients
Who cites it
202 citing papers in PubMed, 4 syntheses or guidelines pooled it, 579 citations in OpenAlex.
- Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Vitamin D Supplementation for Childhood Asthma: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Trial
- Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function.The Journal of allergy and clinical immunology · 2016Trial
- Trial
- Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol.The Journal of allergy and clinical immunology · 2015Trial
- Effects of Vitamin D Intake on FEV1 and COPD Exacerbation: A Randomized Clinical Trial Study.Global journal of health science · 2015Trial
- Trial
- Trial
- The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children.Contemporary clinical trials · 2014Trial
- Trial
- Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients.BMC gastroenterology · 2014Trial
- High-dose cholecalciferol supplementation significantly increases peripheral CD4⁺ Tregs in healthy adults without negatively affecting the frequency of other immune cells.European journal of nutrition · 2014Trial
- Cluster analysis of obesity and asthma phenotypes.PloS one · 2012Trial
- Trial
- Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study.The Journal of allergy and clinical immunology · 2010Trial
- Vitamin D levels, lung function, and steroid response in adult asthma.American journal of respiratory and critical care medicine · 2010Trial
- Patterns of inhaled corticosteroid use and asthma control in the Childhood Asthma Management Program Continuation Study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2010Trial
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported that human CD4+ Tregs secrete high levels of IL-10 when stimulated in the presence of dexamethasone and calcitriol (vitamin D3). We now show that following stimulation by allergen, IL-10-secreting Tregs inhibit cytokine secretion by allergen-specific Th2 cells in an IL-10-dependent manner. A proportion of patients with severe asthma fail to demonstrate clinical improvement upon glucocorticoid therapy, and their asthma is characterized as glucocorticoid resistant (SR, abbreviation derived from "steroid resistant"). Dexamethasone does not enhance secretion of IL-10 by their CD4+ T cells. Addition of vitamin D3 with dexamethasone to cultures of SR CD4+ T cells enhanced IL-10 synthesis to levels observed in cells from glucocorticoid-sensitive patients cultured with dexamethasone alone. Furthermore, pretreatment with IL-10 fully restored IL-10 synthesis in these cells in response to dexamethasone. Vitamin D3 significantly overcame the inhibition of glucocorticoid-receptor expression by dexamethasone while IL-10 upregulated glucocorticoid-receptor expression by CD4+ T cells, suggesting potential mechanisms whereby these treatments may overcome poor glucocorticoid responsiveness. We show here that administration of vitamin D3 to healthy individuals and SR asthmatic patients enhanced subsequent responsiveness to dexamethasone for induction of IL-10. This strongly suggests that vitamin D3 could potentially increase the therapeutic response to glucocorticoids in SR patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.