ArticleGenes and immunity2006
Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Mapping candidate non-MHC susceptibility regions to multiple sclerosis.Genes and immunity · 2006Pooled it
- Article
- Genetics and pathogenesis of multiple sclerosis.Seminars in immunology · 2009Review
- Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.Genes and immunity · 2009Article
- Candidate gene analysis of selectin cluster in patients with multiple sclerosis.Journal of neurology · 2009Article
- SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach.BMC genomics · 2007Article
- Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes.Neurogenetics · 2007Article
- Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.BMC proceedings · 2007Article
- Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease with a strong genetic component. Numerous studies have failed to consistently identify genes that confer disease susceptibility except for association with HLA-DR. Seven non-HLA regions (1q, 2q, 9q, 13q, 16q, 18p and 19q) identified in a recent genomic screen were investigated by genotyping approximately 20 single-nucleotide polymorphisms (SNPs) at approximately 1 Mb intervals. Non-parametric multipoint analyses identified a peak LOD* score of 2.99 for the 1q44 region and substantially narrowed the linkage peak to approximately 7 Mb. Ordered subset analyses (OSA) identified significant LOD score increases for 2q35 and 18p11 when ranking families by HLA-DR status and identified a significant LOD score increase in region 2q35 when ranking families by linkage to chromosome 1q44. 1q44 is particularly interesting because of linkage evidence for this region in studies of both rheumatoid arthritis and systemic lupus erythematosus.
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