ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2006
Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis.Journal of biomedical science · 2023Article
- Serum Extracellular Vesicle Stratifin Is a Biomarker of Perineural Invasion in Patients With Colorectal Cancer and Predicts Worse Prognosis.Frontiers in oncology · 2022Article
- Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via β1-integrin inactivation.American journal of cancer research · 2020Article
- HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma.Journal of cellular and molecular medicine · 2018Article
- Mammalian HspB1 (Hsp27) is a molecular sensor linked to the physiology and environment of the cell.Cell stress & chaperones · 2017Review
- Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe.Cell stress & chaperones · 2016Article
- An in vitro assessment of liposomal topotecan simulating metronomic chemotherapy in combination with radiation in tumor-endothelial spheroids.Scientific reports · 2015Article
- HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins.Cancers · 2014Article
- Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN.Cell stress & chaperones · 2013Article
- SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell.Molecular and cellular biochemistry · 2013Article
- Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update.Archives of toxicology · 2013Review
- Overexpression of SASH1 related to the decreased invasion ability of human glioma U251 cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Effects of SASH1 on lung cancer cell proliferation, apoptosis, and invasion in vitro.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease.BMC cancer · 2012Article
- Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression.Histochemistry and cell biology · 2012Article
- Pathology-dependent effects linked to small heat shock proteins expression: an update.Scientifica · 2012Review
- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics.Translational oncology · 2011Article
- Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB.Breast cancer research : BCR · 2011Article
- Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2010Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
The 25-kDa heat shock protein (Hsp25) is associated with various malignancies and is expressed at high levels in biopsies as well as circulating in the serum of breast cancer patients. In this study, we used RNA interference technology to silence the hsp25 gene in 4T1 breast adenocarcinoma cells, known as a poorly immunogenic, highly metastatic cell line. We demonstrate that transfection of 4T1 cells with short interference RNA-Hsp25 dramatically inhibits proliferation as compared with control transfected cells. In addition, we show that 4T1 cells transfected with short interference RNA-Hsp25 abrogates tumor migration potential by a mechanism that is in part due to the repression of matrix metalloproteinase 9 expression and a concomitant upregulation of its antagonist, tissue inhibitor metalloproteinase 1. Taken together, these findings provide a model system for the study of metastatic potential of tumors and are suggestive of an earlier unrecognized role for Hsp25 in tumor migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.