ReviewAmerican journal of physiology. Renal physiology2006
Regulation of ROMK (Kir1.1) channels: new mechanisms and aspects.
Review in American journal of physiology. Renal physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- The endocytic adaptor ARH facilitates potassium conservation by regulating ROMK and BK.American journal of physiology. Renal physiology · 2025Article
- The cellular pathways that maintain the quality control and transport of diverse potassium channels.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Renal KFrontiers in physiology · 2023Review
- Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.Frontiers in pharmacology · 2023Review
- Potassium Metabolism and Management in Patients with CKD.Nutrients · 2021Review
- Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension.Physiological reviews · 2019Review
- Potassium Channelopathies and Gastrointestinal Ulceration.Gut and liver · 2016Review
- Interstitial 11q24 deletion: a new case and review of the literature.Journal of applied genetics · 2016Review
- Maintaining KAmerican journal of physiology. Renal physiology · 2016Review
- Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion.The Journal of biological chemistry · 2016Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Regulation of Potassium Homeostasis.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype.Human molecular genetics · 2014Article
- Inhibitors of the renal outer medullary potassium channel.ACS medicinal chemistry letters · 2013Article
- Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway.American journal of physiology. Renal physiology · 2012Article
- Differential diagnosis of hyperkalemia: an update to a complex problem.Hippokratia · 2012Article
- Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron.American journal of physiology. Renal physiology · 2012Article
- Protein kinase C mediated pH(i)-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism.Journal of molecular modeling · 2012Article
- Tempol prevents altered K(+) channel regulation of afferent arteriolar tone in diabetic rat kidney.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction.Clinical and experimental nephrology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This brief review attempts to provide an overview regarding recent developments in the regulation of ROMK channels. Studies performed in ROMK null mice suggest that ROMK cannot only form hometetramers such as the small-conductance (30-pS) K channels but also construct heterotetramers such as the 70-pS K channel in the thick ascending limb (TAL). The expression of ROMK channels in the plasma membrane is regulated by protein tyrosine kinase (PTK), serum and glucorticoid-induced kinase (SGK), and with-no-lysine-kinase 4. PTK is involved in mediating the effect of low K intake on ROMK channel activity. Increases in superoxide anions induced by low dietary K intake are responsible for the stimulation of PTK expression and tyrosine phosphorylation of ROMK channels. Finally, a recent study indicated that ROMK channels can be monoubiquitinated and monoubiquitination regulates the surface expression of ROMK channels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.