ArticleEukaryotic cell2005
MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Analysis of the role of acetylation inFrontiers in microbiology · 2024Article
- Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii.Genomics, proteomics & bioinformatics · 2023Article
- A Leak-Free Inducible CRISPRi/a System for Gene Functional Studies in Plasmodium falciparum.Microbiology spectrum · 2022Article
- Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii.BMC biology · 2020Article
- Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii.Antimicrobial agents and chemotherapy · 2016Article
- Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii.The Journal of biological chemistry · 2013Article
- T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.Mutagenesis · 2013Article
- Toxoplasma histone acetylation remodelers as novel drug targets.Expert review of anti-infective therapy · 2012Review
- Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.Eukaryotic cell · 2012Article
- Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives.Trends in parasitology · 2012Review
- Nuclear actin-related protein is required for chromosome segregation in Toxoplasma gondii.Molecular and biochemical parasitology · 2012Article
- Involvement of a Toxoplasma gondii chromatin remodeling complex ortholog in developmental regulation.PloS one · 2011Article
- T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest.PloS one · 2010Article
- The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum.Molecular microbiology · 2010Article
- A decade of epigenetic research in Toxoplasma gondii.Molecular and biochemical parasitology · 2010Review
- MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.The Journal of biological chemistry · 2010Article
- Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle.PLoS pathogens · 2010Article
- The role of DNA microarrays in Toxoplasma gondii research, the causative agent of ocular toxoplasmosis.Journal of ocular biology, diseases, and informatics · 2009Article
- The nsdC gene encoding a putative C2H2-type transcription factor is a key activator of sexual development in Aspergillus nidulans.Genetics · 2009Article
- Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review.Memorias do Instituto Oswaldo Cruz · 2009Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The restructuring of chromatin precedes tightly regulated events such as DNA transcription, replication, and repair. One type of chromatin remodeling involves the covalent modification of nucleosomes by histone acetyltransferase (HAT) complexes. The observation that apicidin exerts antiprotozoal activity by targeting a histone deacetyltransferase has prompted our search for more components of the histone modifying machinery in parasitic protozoa. We have previously identified GNAT family HATs in the opportunistic pathogen Toxoplasma gondii and now describe the first MYST (named for members MOZ, Ybf2/Sas3, Sas2, and Tip60) family HATs in apicomplexa (TgMYST-A and -B). The TgMYST-A genomic locus is singular and generates a approximately 3.5-kb transcript that can encode two proteins of 411 or 471 amino acids. TgMYST-B mRNA is approximately 7.0 kb and encodes a second MYST homologue. In addition to the canonical MYST HAT catalytic domain, both TgMYST-A and -B possess an atypical C2HC zinc finger and a chromodomain. Recombinant TgMYST-A exhibits a predilection to acetylate histone H4 in vitro at lysines 5, 8, 12, and 16. Antibody generated to TgMYST-A reveals that both the long and short (predominant) versions are present in the nucleus and are also plentiful in the cytoplasm. Moreover, both TgMYST-A forms are far more abundant in rapidly replicating parasites (tachyzoites) than encysted parasites (bradyzoites). A bioinformatics survey of the Toxoplasma genome reveals numerous homologues known to operate in native MYST complexes. The characterization of TgMYST HATs represents another important step toward understanding the regulation of gene expression in pathogenic protozoa and provides evolutionary insight into how these processes operate in eukaryotic cells in general.
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