ArticleJournal of immunology (Baltimore, Md. : 1950)2005
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.
Article in Journal of immunology (Baltimore, Md. : 1950), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- PD-L1-CD80 interactions are required for intracellular signaling necessary for dendritic cell migration.Science advances · 2025Article
- Blockade of trans PD-L1 interaction with CD80 augments antitumor immunity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.Molecular cancer research : MCR · 2022Article
- Article
- B7-1 and GM-CSF enhance the anti-tumor immune effect of DC-tumor fusion vaccine in the treatment of prostate cancer.Medical oncology (Northwood, London, England) · 2020Article
- Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions.Nature communications · 2019Article
- TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells.Frontiers in immunology · 2018Article
- Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition.Frontiers in immunology · 2016Review
- Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.Frontiers in immunology · 2016Review
- A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility.The Journal of cell biology · 2015Article
- The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response.Immunology and cell biology · 2015Article
- Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility.Molecular and cellular biology · 2014Article
- Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation.Immunological reviews · 2013Review
- The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.Advances in pharmacology (San Diego, Calif.) · 2013Review
- Micro- and nanoscale engineering of cell signaling.Annual review of biomedical engineering · 2013Review
- Article
- Substrate rigidity regulates human T cell activation and proliferation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells.PloS one · 2012Article
- Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The binding of costimulatory ligand CD80 to CD28 or CTLA-4 on T cells plays an important role in the regulation of the T cell response. We have examined the role of the cytoplasmic domain of CD80 in murine T cell costimulation and its organization in the immunological synapse (IS). Removal of CD80 cytoplasmic tail decreased its effectiveness in costimulating T cell proliferative response and early IL-2 production in response to agonist MHC-peptide complexes. Immunofluorescent study showed a decreased tailless CD80 accumulation in the IS of naive T cells. The two forms of CD80 accumulated differently at the IS; the tailless CD80 was colocalized with the TCR whereas the full-length CD80 was segregated from the TCR. In addition, we showed that CD80, CD28, and protein kinase Ctheta colocalized in the presence or absence of the CD80 cytoplasmic tail. Thus, the cytoplasmic tail of CD80 regulates its spatial localization at the IS and that of its receptors and T cell signaling molecules such as protein kinase Ctheta, and thereby facilitates full T cell activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.