ArticleGenome research2005
Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer-Neurodegeneration Paradox.International journal of molecular sciences · 2026Review
- Genomics and transcriptomics in veterinary oncology.Oncology letters · 2021Review
- Clinical Cytogenetics of the Dog: A Review.Animals : an open access journal from MDPI · 2021Review
- Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers.Veterinary and comparative oncology · 2018Article
- Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2.Frontiers in oncology · 2018Article
- Absence/presence calling in microarray-based CGH experiments with non-model organisms.Nucleic acids research · 2014Article
- MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.Orphanet journal of rare diseases · 2013Article
- Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines.PloS one · 2012Article
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- The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines.BMC cancer · 2011Article
- A compendium of canine normal tissue gene expression.PloS one · 2011Article
- Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.BMC cancer · 2010Article
- Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas.Neuro-oncology · 2010Article
- Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.BMC genomics · 2009Article
- 'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors.Journal of neuro-oncology · 2009Article
- A multiway analysis for identifying high integrity bovine BACs.BMC genomics · 2009Article
- Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Recognition of the domestic dog as a model for the comparative study of human genetic traits has led to major advances in canine genomics. The pathophysiological similarities shared between many human and dog diseases extend to a range of cancers. Human tumors frequently display recurrent chromosome aberrations, many of which are hallmarks of particular tumor subtypes. Using a range of molecular cytogenetic techniques we have generated evidence indicating that this is also true of canine tumors. Detailed knowledge of these genomic abnormalities has the potential to aid diagnosis, prognosis, and the selection of appropriate therapy in both species. We recently improved the efficiency and resolution of canine cancer cytogenetics studies by developing a small-scale genomic microarray comprising a panel of canine BAC clones representing subgenomic regions of particular interest. We have now extended these studies to generate a comprehensive canine comparative genomic hybridization (CGH) array that comprises 1158 canine BAC clones ordered throughout the genome with an average interval of 2 Mb. Most of the clones (84.3%) have been assigned to a precise cytogenetic location by fluorescence in situ hybridization (FISH), and 98.5% are also directly anchored within the current canine genome assembly, permitting direct translation from cytogenetic aberration to DNA sequence. We are now using this resource routinely for high-throughput array CGH and single-locus probe analysis of a range of canine cancers. Here we provide examples of the varied applications of this resource to tumor cytogenetics, in combination with other molecular cytogenetic techniques.
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Registered trials
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