ArticleGenome research2005
Selective sweep mapping of genes with large phenotypic effects.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 130 citations in OpenAlex.
- Response to Two Standardized Exercise Tests in Dogs with Different Cephalic Biotypes.Veterinary sciences · 2025Article
- Signatures of selection in Angus and Hanwoo beef cattle using imputed whole genome sequence data.Frontiers in genetics · 2024Article
- The Shape of the Nasal Cavity and Adaptations to Sniffing in the Dog (Animals : an open access journal from MDPI · 2022Review
- Insight into the Candidate Genes and Enriched Pathways Associated with Height, Length, Length to Height Ratio and Body-Weight of Korean Indigenous Breed, Jindo Dog Using Gene Set Enrichment-Based GWAS Analysis.Animals : an open access journal from MDPI · 2021Article
- Shorter headed dogs, visually cooperative breeds, younger and playful dogs form eye contact faster with an unfamiliar human.Scientific reports · 2021Article
- Transcriptome Analyses Throughout Chili Pepper Fruit Development Reveal Novel Insights into the Domestication Process.Plants (Basel, Switzerland) · 2021Article
- Comparative Signatures of Selection Analyses Identify Loci Under Positive Selection in the Murrah Buffalo of India.Frontiers in genetics · 2021Article
- A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data.Molecular biology and evolution · 2020Article
- Screening for epistatic selection signatures: A simulation study.Scientific reports · 2019Article
- Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews.Genes · 2018Article
- A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: Testing colocalization among outlier markers, candidate genes, and quantitative trait loci for production traits.Evolutionary applications · 2017Article
- Breeding signature of combining ability improvement revealed by a genomic variation map from recurrent selection population in Brassica napus.Scientific reports · 2016Article
- Identification of genomic variants putatively targeted by selection during dog domestication.BMC evolutionary biology · 2016Article
- Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication.Molecular ecology · 2016Review
- A genetic assessment of the English bulldog.Canine genetics and epidemiology · 2016Article
- Strategies for the management and prevention of conformation-related respiratory disorders in brachycephalic dogs.Veterinary medicine (Auckland, N.Z.) · 2015Review
- The relationship of GH and LEP gene polymorphisms with fat-tail measurements (fat-tail dimensions) in fat-tailed Makooei breed of Iranian sheep.Advanced biomedical research · 2015Article
- Impact of Facial Conformation on Canine Health: Brachycephalic Obstructive Airway Syndrome.PloS one · 2015Article
- Strong selection for behavioural resilience in Australian stock working dogs identified by selective sweep analysis.Canine genetics and epidemiology · 2015Article
- An interpretive review of selective sweep studies in Bos taurus cattle populations: identification of unique and shared selection signals across breeds.Frontiers in genetics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Many domestic dog breeds have originated through fixation of discrete mutations by intense artificial selection. As a result of this process, markers in the proximity of genes influencing breed-defining traits will have reduced variation (a selective sweep) and will show divergence in allele frequency. Consequently, low-resolution genomic scans can potentially be used to identify regions containing genes that have a major influence on breed-defining traits. We model the process of breed formation and show that the probability of two or three adjacent marker loci showing a spurious signal of selection within at least one breed (i.e., Type I error or false-positive rate) is low if highly variable and moderately spaced markers are utilized. We also use simulations with selection to demonstrate that even a moderately spaced set of highly polymorphic markers (e.g., one every 0.8 cM) has high power to detect regions targeted by strong artificial selection in dogs. Further, we show that a gene responsible for black coat color in the Large Munsterlander has a 40-Mb region surrounding the gene that is very low in heterozygosity for microsatellite markers. Similarly, we survey 302 microsatellite markers in the Dachshund and find three linked monomorphic microsatellite markers all within a 10-Mb region on chromosome 3. This region contains the FGFR3 gene, which is responsible for achondroplasia in humans, but not in dogs. Consequently, our results suggest that the causative mutation is a gene or regulatory region closely linked to FGFR3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.