ArticleGenome research2005
Hotspots of mutation and breakage in dog and human chromosomes.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
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- Cytogenetics, genomics and biodiversity of the South American and African Arapaimidae fish family (Teleostei, Osteoglossiformes).PloS one · 2019Article
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- Rearrangement hotspots in the sex chromosome of the Palearctic black fly Simulium bergi (Diptera, Simuliidae).Comparative cytogenetics · 2016Article
- Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype.Scientific reports · 2014Article
- DNA damage response and DNA repair - dog as a model?BMC cancer · 2014Article
- Novel origins of copy number variation in the dog genome.Genome biology · 2012Article
- Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.Genome research · 2012Article
- Comparative genomics and evolution of the alpha-defensin multigene family in primates.Molecular biology and evolution · 2010Article
- Comparative genomics reveals birth and death of fragile regions in mammalian evolution.Genome biology · 2010Article
- Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation.BMC genomics · 2009Article
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- Breakpoint graphs and ancestral genome reconstructions.Genome research · 2009Article
- Reduced purifying selection prevails over positive selection in human copy number variant evolution.Genome research · 2008Article
- The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements.BMC genomics · 2008Article
- The evolution of the DLK1-DIO3 imprinted domain in mammals.PLoS biology · 2008Article
- Addressing chromosome evolution in the whole-genome sequence era.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Are there rearrangement hotspots in the human genome?PLoS computational biology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequencing of the dog genome allows an investigation of the location-dependent evolutionary processes that occurred since the common ancestor of primates and carnivores, approximately 95 million years ago. We investigated variations in G+C nucleotide fraction and synonymous nucleotide substitution rates (Ks) across dog and human genomes. Our results show that dog genes located either in subtelomeric and pericentromeric regions, or in short synteny blocks, possess significantly elevated G+C fraction and Ks values. Human subtelomeric, but not pericentromeric, genes also exhibit these elevations. We then examined 1.048 Gb of human sequence that is likely not to have been located near a primate telomere at any time since the common ancestor of dog and human. We observed that regions of highest G+C or Ks ("hotspots"; median sizes of 0.5 or 1.3 Mb, respectively) within this sequence were preferentially segregated to dog subtelomeres and pericentromeres during the rearrangements that eventually gave rise to the extant canine karyotype. Our data cannot be accounted for solely on the basis of gradually elevating G+C fractions in subtelomeric regions as a consequence of biased gene conversion. Rather, we propose that high G+C sequences are found preferentially within dog subtelomeres as a direct consequence of chromosomal fission occurring more frequently within regions elevated in G+C.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.