ArticleThe Journal of physiology2006
Control of interneurone firing pattern by axonal autoreceptors in the juvenile rat cerebellum.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- Excitability Tuning of Axons by Afterdepolarization.Frontiers in cellular neuroscience · 2019Review
- Antidromic Analog Signaling.Frontiers in cellular neuroscience · 2019Review
- Axonal GABAThe Journal of physiology · 2017Article
- Temporal integration and 1/Journal of neurophysiology · 2017Article
- Rapid State-Dependent Alteration in KCell reports · 2017Article
- Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.The Journal of general physiology · 2015Article
- Estimating functional connectivity in an electrically coupled interneuron network.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Activation of axonal receptors by GABA spillover increases somatic firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Measuring the firing rate of high-resistance neurons with cell-attached recording.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrain.Neural development · 2011Article
- Two distinct and activity-dependent mechanisms contribute to autoreceptor-mediated inhibition of GABAergic afferents to hilar mossy cells.The Journal of physiology · 2010Article
- Electrophysiological events recorded at presynaptic terminals of the crayfish neuromuscular junction with a voltage indicator.The Journal of physiology · 2008Article
- Enhancement of GABA release through endogenous activation of axonal GABA(A) receptors in juvenile cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Presynaptic AMPA and kainate receptors increase the size of GABAergic terminals and enhance GABA release.Neuropharmacology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent work has shown that certain neurones have axonal GABA(A) receptors, whose tonic activation modifies their firing properties and neurotransmitter release capability. In addition, results obtained in interneurones of the molecular layer of the cerebellum indicate that action potential-released GABA binds back to the axon that released it, generating an autoreceptor current. In the present paper, we show that at physiological Cl(i)- concentration (15 mm) and at 34-36 degrees C, the autoreceptor current generates a large amplitude (up to 21 mV) after depolarization that lasts for about 150 ms, and that occasionally leads to double firing. Furthermore we show that elimination of the after depolarization, by either blocking GABA(A) receptors, or eliminating the autoreceptor currents through prolonged whole-cell recording, decreases burst firing. I(h) (a hyperpolarization-activated current) was previously found to be prominent in interneurone axons. We show that blocking I(h) leads to an increase in the amplitude of the autoreceptor current as well as of the associated after depolarization, suggesting a shunting effect of I(h) on autoreceptor-mediated after depolarization. Conversely, blocking I(h) accentuates burst firing. The effects of autoreceptor-mediated after depolarization on firing are prominent during a period of development when interneurone synapses are stabilized and vanish by postnatal day 17 (PN 17), together with the expression of the autoreceptor current. Altogether, this work reveals a new role for autoreceptors in the regulation of cell excitability and firing pattern, which may contribute to the development and stabilization of the cerebellar network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.