ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 109 citations in OpenAlex.
- Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability.Science advances · 2024Article
- The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity.eLife · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity.Frontiers in synaptic neuroscience · 2021Article
- Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance.eLife · 2020Article
- Gαq protein signaling in the bed nucleus of the stria terminalis regulate the lipopolysaccharide-induced despair-like behavior in mice.AIMS neuroscience · 2020Article
- αFrontiers in pharmacology · 2020Review
- Association of the PLCB1 gene with drug dependence.Scientific reports · 2017Article
- Modulation of Synaptic Plasticity in the Cortex Needs to Understand All the Players.Frontiers in synaptic neuroscience · 2017Review
- Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity.Journal of neurophysiology · 2016Article
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- Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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- Neuromodulation of neurons and synapses.Current opinion in neurobiology · 2014Review
- Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- β-Adrenoceptors and synaptic plasticity in the perirhinal cortex.Neuroscience · 2014Article
- Failed stabilization for long-term potentiation in the auditory cortex of FMR1 knockout mice.PloS one · 2014Article
- Adrenergic gating of Hebbian spike-timing-dependent plasticity in cortical interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of alpha1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP3). LTD was also impaired by intracellular application of PLC or IP3 receptor blockers, and it was absent in mice lacking PLCbeta1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.