ArticleAmerican journal of physiology. Cell physiology2006
Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak.
Article in American journal of physiology. Cell physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases.Aging and disease · 2025Pooled it
- Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration.PLoS biology · 2023Article
- The Retinal Pigment Epithelium: Cells That Know the Beat!Advances in experimental medicine and biology · 2023Article
- Regulation of the rhythmic diversity of daily photoreceptor outer segment phagocytosis in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Review
- Molecular determinants of αVβ5 localization in flat clathrin lattices - role of αVβ5 in cell adhesion and proliferation.Journal of cell science · 2022Article
- A Splicing Mutation inInternational journal of molecular sciences · 2022Article
- Intrinsic signal optoretinography of dark adaptation kinetics.Scientific reports · 2022Article
- Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion.PloS one · 2022Article
- Loss of Ciliary GeneFrontiers in cell and developmental biology · 2021Article
- Genes Involved in Energy Metabolism Are Differentially Expressed During the Day-Night Cycle in Murine Retinal Pigment Epithelium.Investigative ophthalmology & visual science · 2020Article
- The cell biology of the retinal pigment epithelium.Progress in retinal and eye research · 2020Review
- The Impact of miRNAs in Health and Disease of Retinal Pigment Epithelium.Frontiers in cell and developmental biology · 2020Review
- Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling.Frontiers in immunology · 2020Review
- Identification of genes associated with primary open-angle glaucoma by bioinformatics approach.International ophthalmology · 2018Article
- Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye.Autophagy · 2017Article
- Molecular basis for photoreceptor outer segment architecture.Progress in retinal and eye research · 2016Review
- Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ.Investigative ophthalmology & visual science · 2016Article
- Article
- Mertk deficiency alters expression of micrornas in the retinal pigment epithelium cells.Metabolic brain disease · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
alpha(v)beta(5)-Integrin is the sole integrin receptor at the retinal pigment epithelium (RPE)-photoreceptor interface and promotes RPE phagocytic signaling to the tyrosine kinase Mer tyrosine kinase (MerTK) once a day in response to circadian photoreceptor shedding. Herein we identify a novel role for alpha(v)beta(5)-integrin in permanent RPE-photoreceptor adhesion that is independent of alpha(v)beta(5)'s function in retinal phagocytosis. To compare retinal adhesion of wild-type and beta(5)-integrin(-/-) mice, we mechanically separated RPE and neural retina and quantified RPE protein and pigment retention with the neural retina. Lack of alpha(v)beta(5)-integrin with normal expression of other RPE integrins greatly weakened retinal adhesion in young mice and accelerated its age-dependent decline. Unexpectedly, the strength of wild-type retinal adhesion varied with a diurnal rhythm that peaked 3.5 h after light onset, after the completion of phagocytosis, when integrin signaling to MerTK is minimal. Permanent alpha(v)beta(5) receptor deficiency attenuated the diurnal peak of retinal adhesion in beta(5)-integrin(-/-) mice. These results identify alpha(v)beta(5)-integrin as the first RPE receptor that contributes to retinal adhesion, a vital mechanism for long-term photoreceptor function and viability. Furthermore, they indicate that alpha(v)beta(5) receptors at the same apical plasma membrane domain of RPE cells fulfill two separate functions that are synchronized by different diurnal rhythms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.