ArticleNeuron2005
Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.
Article in Neuron, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 153 citations in OpenAlex.
- A Review of EEG-based Localization of Epileptic Seizure Foci: Common Points with Multimodal Fusion of Brain Data.Journal of medical signals and sensors · 2024Review
- Epileptic seizure focus detection from interictal electroencephalogram: a survey.Cognitive neurodynamics · 2023Review
- Enhanced burst discharges in the CA1 area of the immature versus adult hippocampus: patterns and cellular mechanisms.Journal of neurophysiology · 2022Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Modeling genetic epileptic encephalopathies using brain organoids.EMBO molecular medicine · 2021Article
- Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details.Epilepsia · 2021Article
- On the origin of ultraslow spontaneous NaJournal of neurophysiology · 2021Article
- Case Report: High-Gamma Oscillations on an Ictal Electroencephalogram in a Newborn Patient With Hypoxic-Ischemic Encephalopathy.Frontiers in pediatrics · 2021Article
- When Are Depolarizing GABAergic Responses Excitatory?Frontiers in molecular neuroscience · 2021Review
- The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review.Frontiers in neurology · 2021Review
- Double-Step Machine Learning Based Procedure for HFOs Detection and Classification.Brain sciences · 2020Article
- Bilateral Synchronization of Hippocampal Early Sharp Waves in Neonatal Rats.Frontiers in cellular neuroscience · 2019Article
- Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.Molecular psychiatry · 2018Article
- Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis.Journal of biomedical science · 2017Review
- Detecting and characterizing high-frequency oscillations in epilepsy: a case study of big data analysis.Royal Society open science · 2017Article
- Time-Frequency Strategies for Increasing High-Frequency Oscillation Detectability in Intracerebral EEG.IEEE transactions on bio-medical engineering · 2016Article
- Activation of specific neuronal networks leads to different seizure onset types.Annals of neurology · 2016Article
- GABAergic Synchronization in Epilepsy.Cold Spring Harbor perspectives in medicine · 2016Review
- Is birth a critical period in the pathogenesis of autism spectrum disorders?Nature reviews. Neuroscience · 2015Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABA excites immature neurons and inhibits adult ones, but whether this contributes to seizures in the developing brain is not known. We now report that in the developing, but not the adult, hippocampus, seizures beget seizures only if GABAergic synapses are functional. In the immature hippocampus, seizures generated with functional GABAergic synapses include fast oscillations that are required to transform a naive network to an epileptic one: blocking GABA receptors prevents the long-lasting sequels of seizures. In contrast, in adult neurons, full blockade of GABA(A) receptors generates epileptogenic high-frequency seizures. Therefore, purely glutamatergic seizures are not epileptogenic in the developing hippocampus. We suggest that the density of glutamatergic synapses is not sufficient for epileptogenesis in immature neurons; excitatory GABAergic synapses are required for that purpose. We suggest that the synergistic actions of GABA and NMDA receptors trigger the cascades involved in epileptogenesis in the developing hippocampus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.