ArticleJournal of autoimmunity2006
The mitochondrial and kidney disease phenotypes of kd/kd mice under germfree conditions.
Article in Journal of autoimmunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions.American journal of physiology. Renal physiology · 2024Review
- Causal Effects of Specific Gut Microbiota on Chronic Kidney Diseases and Renal Function-A Two-Sample Mendelian Randomization Study.Nutrients · 2023Article
- Association between gut dysbiosis and chronic kidney disease: a narrative review of the literature.The Journal of international medical research · 2021Review
- Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice.International journal of molecular sciences · 2021Article
- Gut microbial metabolites as multi-kingdom intermediates.Nature reviews. Microbiology · 2021Review
- Gastrin, via activation of PPARα, protects the kidney against hypertensive injury.Clinical science (London, England : 1979) · 2021Article
- Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Renal Impairment in Obese Mice.International journal of molecular sciences · 2021Article
- Distinct Responses of Gut Microbiota to Jian-Pi-Yi-Shen Decoction Are Associated With Improved Clinical Outcomes in 5/6 Nephrectomized Rats.Frontiers in pharmacology · 2020Article
- The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease.Nature reviews. Nephrology · 2018Review
- The next generation of therapeutics for chronic kidney disease.Nature reviews. Drug discovery · 2016Review
- Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell-Mediated Ureteritis and Hydronephrosis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Mitochondrial Diseases Part I: mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors.Mitochondrion · 2015Review
- Genetics of coenzyme q10 deficiency.Molecular syndromology · 2014Article
- Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10.American journal of physiology. Renal physiology · 2013Article
- Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice.EMBO molecular medicine · 2011Article
- TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α.Laboratory investigation; a journal of technical methods and pathology · 2011Article
- Renal mitochondrial cytopathies.International journal of nephrology · 2011Article
- Collapsing glomerulopathy: beyond serendipity in mouse genetics.Kidney international · 2009Article
- Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2.American journal of physiology. Renal physiology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Interstitial nephritis occurs spontaneously in kd/kd mice, but the mechanisms leading to this disease have not been fully elucidated. The earliest manifestation of a phenotype is the appearance of ultrastructural defects in the mitochondria of mice as young as 42 days of age. To examine the influence of the environment on the phenotype, homozygous B6.kd/kd mice were transferred from specific pathogen-free (SPF) conditions to a germfree (GF) environment, and the development of the disease was observed. The GF state resulted in a highly significant reduction in the frequency of tubulointerstitial nephritis. In addition, GF conditions markedly reduced the appearance of the mitochondrial phenotype, with no sign of mitochondrial abnormalities in GF mice of up to 155 days of age. These results suggest that environmental factors are involved in the progression of all known manifestations of this disease phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.