ArticleThe Journal of allergy and clinical immunology2005
Genetic pleiotropy between asthma and obesity in a community-based sample of twins.
Article in The Journal of allergy and clinical immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Genome-wide linkage analysis for circulating levels of adipokines and C-reactive protein in the Quebec family study (QFS).Journal of human genetics · 2008Trial
- Multi-target Effects of Short-Chain Fatty Acids for Obesity-Related Asthma: Interventional Potential and Challenges.Clinical reviews in allergy & immunology · 2025Review
- Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025Review
- Genome-wide Association Study of Susceptibility Loci for Self-Reported Atopic Dermatitis and Allergic Rhinitis in the Korean Population.Annals of dermatology · 2024Article
- The Role of Peptides in Asthma-Obesity Phenotype.International journal of molecular sciences · 2024Review
- Allergic Diseases and Childhood Obesity: A Detrimental Link?Biomedicines · 2023Review
- Obesity-related asthma and its relationship with microbiota.Frontiers in cellular and infection microbiology · 2023Review
- Leptin and Asthma: What Are the Interactive Correlations?Biomolecules · 2022Review
- The Impact of Dietary Intervention in Obese Children on Asthma Prevention and Control.Nutrients · 2022Review
- An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022Review
- Genetic variations in theExperimental and therapeutic medicine · 2021Article
- Childhood Obesity and Respiratory Diseases: Which Link?Children (Basel, Switzerland) · 2021Review
- Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2.American journal of epidemiology · 2021Article
- Asthma and Obesity in Children.Biomedicines · 2020Review
- A Role for the Rho-GTPase Pathway in Pediatric Obese Asthma.American journal of respiratory and critical care medicine · 2020Article
- Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic.Journal of clinical medicine · 2020Review
- Pediatric obesity-related asthma: A prototype of pediatric severe non-T2 asthma.Pediatric pulmonology · 2020Article
- Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.The Journal of allergy and clinical immunology · 2020Article
- An epistatic interaction between pre-natal smoke exposure and socioeconomic status has a significant impact on bronchodilator drug response in African American youth with asthma.BioData mining · 2020Article
- Bariatric surgery: a potential cure for asthma?European respiratory review : an official journal of the European Respiratory Society · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAsthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes.
objectiveWe sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause.
methodsThe analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects.
resultsA strong association between asthma and BMI was identified in the sample population (P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma.
conclusionThe covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions.
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