ArticleCellular immunology2005
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Article in Cellular immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
- Harnessing therapeutic potential of bromelain and its nanoformulations: sojourn of pineapple from food to nanomedicine.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025Review
- Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-Of Concept Clinical Studies on the First 22 Tumors.Journal of clinical medicine · 2024Article
- Review
- Article
- A pilot study examining a proprietary herbal blend for the treatment of canine osteoarthritis pain.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Beneficial Properties of Bromelain.Nutrients · 2021Review
- Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Foods (Basel, Switzerland) · 2021Review
- Anti-Inflammatory and Mineralization Effects of Bromelain on Lipopolysaccharide-Induced Inflammation of Human Dental Pulp Cells.Medicina (Kaunas, Lithuania) · 2021Article
- Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer.International journal of molecular sciences · 2021Article
- Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective.Life (Basel, Switzerland) · 2021Review
- Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery.Integrative medicine (Encinitas, Calif.) · 2020Review
- Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus.Inflammopharmacology · 2018Article
- Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.Animal cells and systems · 2018Article
- Potential role of bromelain in clinical and therapeutic applications.Biomedical reports · 2016Article
- Application of protease technology in dermatology: rationale for incorporation into skin care with initial observations on formulations designed for skin cleansing, maintenance of hydration, and restoration of the epidermal permeability barrier.The Journal of clinical and aesthetic dermatology · 2013Article
- Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Properties and therapeutic application of bromelain: a review.Biotechnology research international · 2012Article
- LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus Merr.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro.International immunopharmacology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveBromelain, a clinically used pineapple extract and natural product, has reported anti-inflammatory and immunomodulatory activities. The purpose of this study was to determine the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
methodsTo establish AAD, mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols. Mice were treated i.p. with either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days. Bronchoalveolar lavage leukocytes and cytokines, lung histology, airway hyperresponsiveness, and lymphocyte populations via flow cytometry were compared between groups.
resultsBromelain treatment of AAD mice resulted in reduced total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.
conclusionBromelain attenuated development of AAD while altering CD4+ to CD8+ T lymphocyte populations. The reduction in AAD outcomes suggests that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.