ArticleJournal of negative results in biomedicine2005
Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.
Article in Journal of negative results in biomedicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Analysis of amplification and association polymorphisms in the bovine beta-defensin 129 (BBD129) gene revealed its function in bull fertility.Scientific reports · 2022Article
- An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.Frontiers in immunology · 2015Review
- Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 gene.Genome biology and evolution · 2014Article
- Genetic influences on cystic fibrosis lung disease severity.Frontiers in pharmacology · 2013Article
- A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia.Human mutation · 2011Article
- Determination of beta-defensin genomic copy number in different populations: a comparison of three methods.PloS one · 2011Article
- Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease.Human molecular genetics · 2010Article
- Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing.BMC genomics · 2010Article
- Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients.Journal of applied genetics · 2010Article
- Human defensins and LL-37 in mucosal immunity.Journal of leukocyte biology · 2010Review
- An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus.Human mutation · 2009Article
- Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Update on gene modifiers in cystic fibrosis.Current opinion in pulmonary medicine · 2008Review
- Directional and balancing selection in human beta-defensins.BMC evolutionary biology · 2008Article
- Psoriasis is associated with increased beta-defensin genomic copy number.Nature genetics · 2008Article
- Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats.Nucleic acids research · 2007Article
- A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.American journal of human genetics · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation between beta-defensin cluster genomic copy number and lung disease associated with CF. No significant association was found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.