SynthesisJournal of general internal medicine2006
Brief report: Methadone treatment of injecting opioid users for prevention of HIV infection.
Synthesis in Journal of general internal medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Pooled it
- Meta-analyses of seven of the National Institute on Drug Abuse's principles of drug addiction treatment.Journal of substance abuse treatment · 2012Pooled it
- HIV infection and risk of overdose: a systematic review and meta-analysis.AIDS (London, England) · 2012Pooled it
- HIV-Risk Behavior Among Adults with Opioid Use Disorder During 12 Months Following Pre-trial Detention: Results from a Randomized Trial of Methadone Treatment.AIDS and behavior · 2021Trial
- An outbreak of HIV infection among people who inject drugs linked to injection of propofol in Taiwan.PloS one · 2019Trial
- Expanding substance use treatment options for HIV prevention with buprenorphine-naloxone: HIV Prevention Trials Network 058.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Primary care-based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial.JAMA internal medicine · 2014Trial
- HIV risk reduction with buprenorphine-naloxone or methadone: findings from a randomized trial.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Pilot trial of a recovery management intervention for heroin addicts released from compulsory rehabilitation in China.Journal of substance abuse treatment · 2013Trial
- HIV risk behavior in treatment-seeking opioid-dependent youth: results from a NIDA clinical trials network multisite study.Journal of acquired immune deficiency syndromes (1999) · 2010Trial
- Impact of interim methadone maintenance on HIV risk behaviors.Journal of urban health : bulletin of the New York Academy of Medicine · 2010Trial
- Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors.Journal of substance abuse treatment · 2008Trial
- Postprison release HIV-risk behaviors in a randomized trial of methadone treatment for prisoners.The American journal on addictionsTrial
- Delivering HIV-Positive Test Results via Phone: Who Never Answered? Correlates of Undelivered Reactive HIV Results in a U.S. National Cohort of Sexual and Gender Minority Individuals.AIDS and behavior · 2026Article
- Cutaneous Abscess Prevalence and Risk Factors Among People Who Inject Drugs in Denver, Colorado.Open forum infectious diseases · 2025Article
- Considerations when prescribing opioid agonist therapies for people living with HIV.Expert review of clinical pharmacology · 2024Review
- Article
- Interest in treatment with injectable diacetylmorphine among people who use opioids in Baltimore City, Maryland (USA).Annals of medicine · 2023Article
- Challenges to Providing Integrated HIV Prevention in Substance Use Treatment Settings: Frontline Staff Perspectives on HIV and Sex-Related, Education, Communication and Stigma.Substance use & misuse · 2023Article
- Differences in Gut Microbial Diversity are Driven by Drug Use and Drug Cessation by Either Compulsory Detention or Methadone Maintenance Treatment.Microorganisms · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effects of oral substitution treatment for opioid-dependent injecting drug users on HIV risk behaviors and infections. DATA SOURCES: Multiple electronic databases were searched. Reference lists of retrieved articles were checked.
methodsBecause of varying methodologies of available studies, this systematic review was limited to a descriptive summary, looking at consistency of outcomes across studies.
resultsTwenty-eight studies involving methadone treatment were included in the review. Methadone maintenance treatment is associated with statistically significant reductions in injecting use and sharing of injecting equipment. It is also associated with reductions in numbers of injecting drug users reporting multiple sex partners or exchanges of sex for drugs or money, but has little effect on condom use. It appears that the reductions in risk behaviors do translate into fewer cases of HIV infection.
conclusionsMethadone maintenance treatment for injecting drug users significantly reduces the risk of transmission of HIV and should be provided as a component of a strategic approach to the prevention and control of HIV infection. There is insufficient evidence to determine whether other forms of oral substitution treatment also reduce the risk of HIV transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.