ReviewMolecular and cellular biochemistry2005
Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation?
Review in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Nature communications · 2018Pooled it
- A variant of PSMD6 is associated with the therapeutic efficacy of oral antidiabetic drugs in Chinese type 2 diabetes patients.Scientific reports · 2015Trial
- The duplexity of insulin: The integrated bioinformatics analysis and machine learning identified key genes for type 2 diabetes.Biochemistry and biophysics reports · 2025Article
- Role of UPP pathway in amelioration of diabetes-associated complications.Environmental science and pollution research international · 2021Review
- RING finger protein 10 is a potential drug target for diabetic vascular complications.Molecular medicine reports · 2019Article
- Article
- A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.JCI insight · 2018Article
- Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum.Frontiers in pharmacology · 2017Article
- Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD.Cardiovascular research · 2014Article
- Peptide level immunoaffinity enrichment enhances ubiquitination site identification on individual proteins.Molecular & cellular proteomics : MCP · 2014Article
- Role of transcription factor modifications in the pathogenesis of insulin resistance.Experimental diabetes research · 2012Review
- Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress.Free radical biology & medicine · 2011Article
- The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes.Cardiovascular diabetology · 2007Review
- Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats.Endocrine · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent mining of the human and mouse genomes, use of yeast genetics, and detailed analyses of several biochemical pathways, have resulted in the identification of many new roles for ubiquitin-proteasome mediated degradation of proteins. In the context of last year's award of Noble Prize (Chemistry) work, the ubiquitin and ubiquitin-like modifications are increasingly recognized as key regulatory events in health and disease. Although the ATP-dependent ubiquitin-proteasome system has evolved as premier cellular proteolytic machinery, dysregulation of this system by several different mechanisms leads to inappropriate degradation of specific proteins and pathological consequences. While aberrations in the ubiquitin-proteasome pathway have been implicated in certain malignancies and neurodegenerative disorders, recent studies indicate a role for this system in the pathogenesis of diabetes and its complications. Inappropriate degradation of insulin signaling molecules such as insulin receptor substrates (IRS-1 and IRS-2) has been demonstrated in experimental diabetes, mediated in part through the up-regulation of suppressors of cytokine signaling (SOCS). It appears that altered ubiquitin-proteasome system might be one of the molecular mechanisms of insulin resistance in many pathological situations. Drugs that modulate the SOCS action and/or proteasomal degradation of proteins could become novel agents for the treatment of insulin resistance and Type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.