ArticleMolecular and cellular biochemistry2005
High-fat feeding period affects gene expression in rat white adipose tissue.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
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- Interaction between caveolin-1 polymorphism and dietary fat quality indexes on visceral adiposity index (VAI) and body adiposity index (BAI) among overweight and obese women: a cross-sectional study.BMC medical genomics · 2022Article
- Expression of Caveolin 1 is enhanced by DNA demethylation during adipocyte differentiation. status of insulin signaling.PloS one · 2014Article
- Article
- High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling.Lipids in health and disease · 2011Article
- Increased adiposity in the retinol saturase-knockout mouse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Activation of retinoic acid receptors by dihydroretinoids.Molecular pharmacology · 2009Article
- Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers.Molecular and cellular biochemistry · 2007Article
- Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol.Biochemistry · 2007Article
- Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity.Journal of physiology and biochemistry · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of 76 sequences, previously isolated as differentially expressed in visceral white adipose tissue (WAT) of female rats, fed with a high-fat diet for 11 days (Lopez et al., Biochem Biophys Res Comm 318: 234-239, 2004), was analyzed in epidydimal WAT of male rats after a feeding period of 65 days with the same diet, using microarray technology. After Northern blot validation of the results, only three genes appeared upregulated (caveolin-2, the alpha-1 chain of haemoglobin and rat mammary tumor-7) and two downregulated (adiponectin and dystroglycan). We have also analyzed caveolin-1 gene expression and found that follows the opposite pattern of caveolin-2, indicating that they are inversely regulated. Our results suggest that if feeding with a high-fat diet is prolonged, many of the initial changes in gene expression, probably aimed to consume the energy surplus and prevent excessive fat deposition, are not maintained, and adaptation to an increased lipid storage is developed.
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