ArticleMolecular and cellular biochemistry2005
Involvement of calpain in melanogenesis of mouse B16 melanoma cells.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- 2,4,6-Triphenyl-1-hexene, an Anti-Melanogenic Compound from Marine-DerivedMarine drugs · 2024Article
- Comparative transcriptomic and proteomic analysis of yellow shell and black shell pearl oysters, Pinctada fucata martensii.BMC genomics · 2019Article
- Src inhibition induces melanogenesis in human G361 cells.Molecular medicine reports · 2019Article
- CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.Oncotarget · 2018Article
- Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes.Scientific reports · 2016Article
- Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2012Article
- Wnt5A activates the calpain-mediated cleavage of filamin A.The Journal of investigative dermatology · 2009Article
- HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity.Biochimica et biophysica acta · 2009Article
- Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents.Drug discovery today. Disease mechanisms · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the current study, the involvement of calpain, a cysteine proteinase in the regulation of melanogenesis was examined using mouse B16 melanoma cells. In response to alpha-melanocyte-stimulating hormone (a-MSH), B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. The total calapain activity was decreased within 2 h following alpha-MSH-treatment, and restored to the initial level in 6-12 h. To further investigate the involvement of calpain in the regulation of melanogenesis, the effect of calpain inhibitors on alpha-MSH-induced melanogenesis was examined. Inhibition of calpain by either N-acetyl-Leu-Leu-norleucinal (ALLN) or calpastatin (CS) peptide blocked alpha-MSH-induced melanogenesis. The magnitude of inhibition of melanin biosynthesis was well correlated with a decrease in the activity of tyrosinase, a key regulatory enzyme in melanogenesis. Treatment of B16 cells with ALLN caused marked decrease in both tyrosinase protein and mRNA levels. These results indicate that calpain would be involved in the melanogenic signaling by modulating the expression of tyrosinase in mouse B16 melanoma cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.