ArticleApplied and environmental microbiology2005
Genetic characterization of the Bifidobacterium breve UCC 2003 hrcA locus.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Stress Response in Bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2022Review
- Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.Applied and environmental microbiology · 2022Article
- Characterization and induction of prophages in human gut-associated Bifidobacterium hosts.Scientific reports · 2018Article
- Targeting the Proteostasis Network for Mycobacterial Drug Discovery.ACS infectious diseases · 2018Review
- Global transcriptional landscape and promoter mapping of the gut commensal Bifidobacterium breve UCC2003.BMC genomics · 2017Article
- Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again.Microbial cell factories · 2011Review
- How do bifidobacteria counteract environmental challenges? Mechanisms involved and physiological consequences.Genes & nutrition · 2011Article
- Genomic insights into bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2010Review
- An interactive regulatory network controls stress response in Bifidobacterium breve UCC2003.Journal of bacteriology · 2009Article
- Molecular characterization of hsp20, encoding a small heat shock protein of bifidobacterium breve UCC2003.Applied and environmental microbiology · 2007Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial heat shock response is characterized by the elevated expression of a number of chaperone complexes and transcriptional regulators, including the DnaJ and the HrcA proteins. Genome analysis of Bifidobacterium breve UCC 2003 revealed a second copy of a dnaJ gene, named dnaJ2, which is flanked by the hrcA gene in a genetic constellation that appears to be unique to the actinobacteria. Phylogenetic analysis using 53 bacterial dnaJ sequences, including both dnaJ1 and dnaJ2 sequences, suggests that these genes have followed a different evolutionary development. Furthermore, the B. breve UCC 2003 dnaJ2 gene seems to be regulated in a manner that is different from that of the previously characterized dnaJ1 gene. The dnaJ2 gene, which was shown to be part of a 2.3-kb bicistronic operon with hrcA, was induced by osmotic shock but not significantly by heat stress. This induction pattern is unlike those of other characterized dnaJ genes and may be indicative of a unique stress adaptation strategy by this commensal microorganism.
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