ArticleApplied and environmental microbiology2005
Community analysis of a mercury hot spring supports occurrence of domain-specific forms of mercuric reductase.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Nanomineral-fueled chemolithoautotrophy leads to substantial mercury emission.National science review · 2026Article
- Expanded Diversity and Phylogeny ofFrontiers in microbiology · 2021Article
- Genome-Resolved Metagenomics and Detailed Geochemical Speciation Analyses Yield New Insights into Microbial Mercury Cycling in Geothermal Springs.Applied and environmental microbiology · 2020Article
- Assessment of spring water quality and associated health risks in a high-level natural radiation area, North Iran.Environmental science and pollution research international · 2020Article
- Molecular Adaptations of Bacterial Mercuric Reductase to the Hypersaline Kebrit Deep in the Red Sea.Applied and environmental microbiology · 2019Article
- Metal-tolerant thermophiles: metals as electron donors and acceptors, toxicity, tolerance and industrial applications.Environmental science and pollution research international · 2018Review
- Culturable and culture-independent bacterial diversity and the prevalence of cold-adapted enzymes from the Himalayan mountain ranges of India and Nepal.Microbial ecology · 2015Article
- Biochemical and Structural Properties of a Thermostable Mercuric Ion Reductase from Metallosphaera sedula.Frontiers in bioengineering and biotechnology · 2015Article
- Role of MerH in mercury resistance in the archaeon Sulfolobus solfataricus.Microbiology (Reading, England) · 2013Article
- Mercury resistance and mercuric reductase activities and expression among chemotrophic thermophilic Aquificae.Applied and environmental microbiology · 2012Article
- Survival of the fittest: overcoming oxidative stress at the extremes of Acid, heat and metal.Life (Basel, Switzerland) · 2012Review
- The mercury resistance operon: from an origin in a geothermal environment to an efficient detoxification machine.Frontiers in microbiology · 2012Article
- Environmental conditions constrain the distribution and diversity of archaeal merA in Yellowstone National Park, Wyoming, U.S.A.Microbial ecology · 2011Article
- Characterization of archaeal community in contaminated and uncontaminated surface stream sediments.Microbial ecology · 2010Article
- Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function.PloS one · 2010Article
- Genotypic microbial community profiling: a critical technical review.Microbial ecology · 2007Review
- The isolation and initial characterization of mercury resistant chemolithotrophic thermophilic bacteria from mercury rich geothermal springs.Extremophiles : life under extreme conditions · 2007Article
- Regulation of mercury resistance in the crenarchaeote Sulfolobus solfataricus.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mercury is a redox-active heavy metal that reacts with active thiols and depletes cellular antioxidants. Active resistance to the mercuric ion is a widely distributed trait among bacteria and results from the action of mercuric reductase (MerA). Protein phylogenetic analysis of MerA in bacteria indicated the occurrence of a second distinctive form of MerA among the archaea, which lacked an N-terminal metal recruitment domain and a C-terminal active tyrosine. To assess the distribution of the forms of MerA in an interacting community comprising members of both prokaryotic domains, studies were conducted at a naturally occurring mercury-rich geothermal environment. Geochemical analyses of Coso Hot Springs indicated that mercury ore (cinnabar) was present at concentrations of parts per thousand. Under high-temperature and acid conditions, cinnabar may be oxidized to the toxic form Hg2+, necessitating mercury resistance in resident prokaryotes. Culture-independent analysis combined with culture-based methods indicated the presence of thermophilic crenarchaeal and gram-positive bacterial taxa. Fluorescence in situ hybridization analysis provided quantitative data for community composition. DNA sequence analysis of archaeal and bacterial merA sequences derived from cultured pool isolates and from community DNA supported the hypothesis that both forms of MerA were present. Competition experiments were performed to assess the role of archaeal merA in biological fitness. An essential role for this protein was evident during growth in a mercury-contaminated environment. Despite environmental selection for mercury resistance and the proximity of community members, MerA retains the two distinct prokaryotic forms and avoids genetic homogenization.
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