ArticleApplied and environmental microbiology2005
Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 158 citations in OpenAlex.
- Towards EffectiveInternational journal of molecular sciences · 2025Review
- Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review.International journal of molecular sciences · 2024Review
- Phytochemicals and Their Usefulness in the Maintenance of Health.Plants (Basel, Switzerland) · 2024Review
- Anti-Heliyon · 2024Article
- The effects and mechanisms of natural products onFrontiers in cellular and infection microbiology · 2024Review
- Review
- Metabolic Profiling by GC-MS,Molecules (Basel, Switzerland) · 2022Article
- The Impact of Plant Phytochemicals on the Gut Microbiota of Humans for a Balanced Life.International journal of molecular sciences · 2022Review
- Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism.Bioinorganic chemistry and applications · 2022Article
- In Vitro Screening Potential Antibacterial Properties of the Greek Oregano Honey against Clinical Isolates ofFoods (Basel, Switzerland) · 2021Article
- Cocktail of chelated minerals and phytogenic feed additives in the poultry industry: A review.Veterinary world · 2021Review
- Article
- Plants againstBiotechnology reports (Amsterdam, Netherlands) · 2020Review
- Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults.Nutrients · 2020Review
- The In Vitro Activity of Essential Oils againstMolecules (Basel, Switzerland) · 2020Article
- Polyphenols in the Fermentation Liquid ofFrontiers in immunology · 2020Article
- In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein andBMC chemistry · 2019Article
- Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency.Nutrients · 2019Review
- Phytochemicals inInternational journal of molecular sciences · 2018Review
- Essential Oils as Feed Additives-Future Perspectives.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcer-associated dyspepsia is caused by infection with Helicobacter pylori. H. pylori is linked to a majority of peptic ulcers. Antibiotic treatment does not always inhibit or kill H. pylori with potential for antibiotic resistance. The objective of this study was to determine the potential for using phenolic phytochemical extracts to inhibit H. pylori in a laboratory medium. Our approach involved the development of a specific phenolic profile with optimization of different ratios of extract mixtures from oregano and cranberry. Subsequently, antimicrobial activity and antimicrobial-linked urease inhibition ability were evaluated. The results indicated that the antimicrobial activity was greater in extract mixtures than in individual extracts of each species. The results also indicate that the synergistic contribution of oregano and cranberry phenolics may be more important for inhibition than any species-specific phenolic concentration. Further, based on plate assay, the likely mode of action may be through urease inhibition and disruption of energy production by inhibition of proline dehydrogenase at the plasma membrane.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.