ArticleApplied and environmental microbiology2005
Complete sequences of four plasmids of Lactococcus lactis subsp. cremoris SK11 reveal extensive adaptation to the dairy environment.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 140 citations in OpenAlex.
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- Advances in Genetic Transformation of Lactic Acid Bacteria: Overcoming Barriers and Enhancing Plasmid Tools.International journal of molecular sciences · 2025Review
- A Plasmid-Encoded Surface Polysaccharide Partly BlocksInternational journal of molecular sciences · 2025Article
- The lactococcal ICE-ome encodes a repertoire of exchangeable traits with potential industrial relevance.BMC genomics · 2024Article
- Detection and classification of the integrative conjugative elements of Lactococcus lactis.BMC genomics · 2024Review
- Phenotypic and Safety Assessment of the Cheese StrainInternational journal of molecular sciences · 2022Article
- Directed Recovery and Molecular Characterization of Antibiotic Resistance Plasmids from Cheese Bacteria.International journal of molecular sciences · 2021Article
- Identification of Nitrogen Fixation Genes inMicroorganisms · 2020Article
- Development ofFrontiers in microbiology · 2020Article
- Modeled Structure of the Cell Envelope Proteinase ofFrontiers in bioengineering and biotechnology · 2020Article
- A Specific Sugar Moiety in the Lactococcus lactis Cell Wall Pellicle Is Required for Infection by CHPC971, a Member of the Rare 1706 Phage Species.Applied and environmental microbiology · 2019Article
- TheFrontiers in microbiology · 2019Article
- Comparative Genome Analysis ofFrontiers in microbiology · 2019Article
- Large plasmidome of dairy Lactococcus lactis subsp. lactis biovar diacetylactis FM03P encodes technological functions and appears highly unstable.BMC genomics · 2018Article
- Comparative genomic analysis of Enterococcus faecalis: insights into their environmental adaptations.BMC genomics · 2018Article
- Dynamics in Copy Numbers of Five Plasmids of a Dairy Lactococcus lactis Strain under Dairy-Related Conditions Including Near-Zero Growth Rates.Applied and environmental microbiology · 2018Article
- Article
- Comparative genomic and metabolic analysis of three Lactobacillus paracasei cheese isolates reveals considerable genomic differences in strains from the same niche.BMC genomics · 2018Article
- Further Elucidation of Galactose Utilization inFrontiers in microbiology · 2018Article
5 more citing papers are in PubMed but not listed here.
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Lactococcus lactis strains are known to carry plasmids encoding industrially important traits. L. lactis subsp. cremoris SK11 is widely used by the dairy industry in cheese making. Its complete plasmid complement was sequenced and found to contain the plasmids pSK11A (10,372 bp), pSK11B (13,332 bp), pSK11L (47,165 bp), and pSK11P (75,814 bp). Six highly homologous repB-containing replicons were found, all belonging to the family of lactococcal theta-type replicons. Twenty-three complete insertion sequence elements segment the plasmids into numerous modules, many of which can be identified as functional units or containing functionally related genes. Plasmid-encoded functions previously known to reside on L. lactis SK11 plasmids were now mapped in detail, e.g., lactose utilization (lacR-lacABCDFEGX), the proteolytic system (prtM-prtP, pepO, pepF), and the oligopeptide permease system (oppDFBCA). Newly identified plasmid-encoded functions could facilitate the uptake of various cations, while the pabA and pabB genes could be essential for folate biosynthesis. A competitive advantage could be obtained by using the putative flavin adenine dinucleotide-dependent d-lactate dehydrogenase and oxalate:formate antiporter for enhanced ATP synthesis, while the activity of the predicted alpha-acetolactate decarboxylase may contribute to the formation of an additional electron sink. Various stress response proteins are plasmid encoded, which could enhance strain robustness. A substantial number of these "adaptation" genes have not been described before on L. lactis plasmids. Moreover, several genes were identified for the first time in L. lactis, possibly reflecting horizontal gene transfer.
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