ArticleApplied and environmental microbiology2005
Characterization and functional analysis of the MAL and MPH Loci for maltose utilization in some ale and lager yeast strains.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 97 citations in OpenAlex.
- A non-GMOFrontiers in microbiology · 2026Article
- Maltose and Maltotriose Transporters in Brewer'sInternational journal of molecular sciences · 2025Review
- Key Amino Acid Residues of the Agt1 Transporter for Trehalose Transport byJournal of fungi (Basel, Switzerland) · 2024Article
- Expression patterns ofApplied and environmental microbiology · 2024Article
- Integrated genomics and phenotype microarray analysis of Saccharomyces cerevisiae industrial strains for rice wine fermentation and recombinant protein production.Microbial biotechnology · 2023Article
- Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation.PLoS genetics · 2022Article
- Kveik Brewing Yeasts Demonstrate Wide Flexibility in Beer Fermentation Temperature Tolerance and Exhibit Enhanced Trehalose Accumulation.Frontiers in microbiology · 2022Article
- Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology.Microbial cell factories · 2021Article
- Packing a punch: understanding how flavours are produced in lager fermentations.FEMS yeast research · 2021Review
- HimalayanApplied and environmental microbiology · 2019Article
- Privatization of public goods can cause population decline.Nature ecology & evolution · 2019Article
- Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function.PLoS genetics · 2019Article
- Trans-regulation and localization of orthologous maltose transporters in the interspecies lager yeast hybrid.FEMS yeast research · 2018Article
- Structural, Physiological and Regulatory Analysis of Maltose Transporter Genes inFrontiers in microbiology · 2018Article
- Copy Number Variation in Fungi and Its Implications for Wine Yeast Genetic Diversity and Adaptation.Frontiers in microbiology · 2018Review
- Evolutionary Engineering in Chemostat Cultures for Improved Maltotriose Fermentation Kinetics inFrontiers in microbiology · 2017Article
- Maltose and maltotriose utilisation by group I strains of the hybrid lager yeast Saccharomyces pastorianus.FEMS yeast research · 2016Article
- Ploidy influences the functional attributes of de novo lager yeast hybrids.Applied microbiology and biotechnology · 2016Article
- New lager yeast strains generated by interspecific hybridization.Journal of industrial microbiology & biotechnology · 2015Article
- Characterization of a new multigene family encoding isomaltases in the yeast Saccharomyces cerevisiae, the IMA family.The Journal of biological chemistry · 2010Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Maltose and maltotriose are the major sugars in brewer's wort. Brewer's yeasts contain multiple genes for maltose transporters. It is not known which of these express functional transporters. We correlated maltose transport kinetics with the genotypes of some ale and lager yeasts. Maltose transport by two ale strains was strongly inhibited by other alpha-glucosides, suggesting the use of broad substrate specificity transporters, such as Agt1p. Maltose transport by three lager strains was weakly inhibited by other alpha-glucosides, suggesting the use of narrow substrate specificity transporters. Hybridization studies showed that all five strains contained complete MAL1, MAL2, MAL3, and MAL4 loci, except for one ale strain, which lacked a MAL2 locus. All five strains also contained both AGT1 (coding a broad specificity alpha-glucoside transporter) and MAL11 alleles. MPH genes (maltose permease homologues) were present in the lager but not in the ale strains. During growth on maltose, the lager strains expressed AGT1 at low levels and MALx1 genes at high levels, whereas the ale strains expressed AGT1 at high levels and MALx1 genes at low levels. MPHx expression was negligible in all strains. The AGT1 sequences from the ale strains encoded full-length (616 amino acid) polypeptides, but those from both sequenced lager strains encoded truncated (394 amino acid) polypeptides that are unlikely to be functional transporters. Thus, despite the apparently similar genotypes of these ale and lager strains revealed by hybridization, maltose is predominantly carried by AGT1-encoded transporters in the ale strains and by MALx1-encoded transporters in the lager strains.
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