ArticleJournal of neuroinflammation2005
Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.
Article in Journal of neuroinflammation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.EMBO molecular medicine · 2018Article
- Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases.Frontiers in neurology · 2017Review
- The MultiTEP platform-based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.Molecular neurodegeneration · 2012Article
- Vaccine Development to Treat Alzheimer's Disease Neuropathology in APP/PS1 Transgenic Mice.International journal of Alzheimer's disease · 2012Article
- Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.Journal of neuroinflammation · 2010Article
- CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model.Journal of Alzheimer's disease : JAD · 2010Article
- Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice.The American journal of pathology · 2009Article
- The role of the anaphylatoxins in health and disease.Molecular immunology · 2009Review
- Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine.Journal of Alzheimer's disease : JAD · 2009Article
- The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration.Journal of neurochemistry · 2008Review
- Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.Journal of Alzheimer's disease : JAD · 2008Review
- Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease.Journal of neurochemistry · 2008Article
- A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Impact of amyloid imaging on drug development in Alzheimer's disease.Nuclear medicine and biology · 2007Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlzheimer's disease, a common dementia of the elder, is characterized by accumulation of protein amyloid deposits in the brain. Immunization to prevent this accumulation has been proposed as a therapeutic possibility, although adverse inflammatory reactions in human trials indicate the need for novel vaccination strategies.
methodHere vaccination with novel amyloid peptide immunogens was assessed in a transgenic mouse model displaying age-related accumulation of fibrillar plaques.
resultsImmunization with any conformation of the amyloid peptide initiated at 12 months of age (at which time fibrillar amyloid has just begun to accumulate) showed significant decrease in total and fibrillar amyloid deposits and in glial reactivity relative to control transgenic animals. In contrast, there was no significant decrease in amyloid deposition or glial activation in mice in which vaccination was initiated at 16 months of age, despite the presence of similar levels anti-Abeta antibodies in young and old animals vaccinated with a given immunogen. Interestingly, immunization with an oligomeric conformation of Abeta was equally as effective as other amyloid peptides at reducing plaque accumulation. However, the antibodies generated by immunization with the oligomeric conformation of Abeta have more limited epitope reactivity than those generated by fAbeta, and the microglial response was significantly less robust.
conclusionThese results suggest that a more specific immunogen such as oligomeric Abeta can be designed that achieves the goal of depleting amyloid while reducing potential detrimental inflammatory reactions. In addition, the data show that active immunization of older Tg2576 mice with any amyloid conformation is not as efficient at reducing amyloid accumulation and related pathology as immunization of younger mice, and that serum anti-amyloid antibody levels are not quantitatively related to reduced amyloid-associated pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.