ArticleBiochemistry2005
Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution.
Article in Biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 158 citations in OpenAlex.
- Phosphoric acid esters cannot replace polyvinylphosphonic acid as phosphoprotein analogs in biomimetic remineralization of resin-bonded dentin.Dental materials : official publication of the Academy of Dental Materials · 2009Trial
- Biomimetic remineralization of resin-bonded acid-etched dentin.Journal of dental research · 2009Trial
- Amyloid-induced mineralization: From biological systems to biomimetic materials.Bioactive materials · 2025Review
- Development of a novel Agarose/Nano-Hydroxyapatite/Grape seed extract hydrogel for biomimetic remineralization of demineralized human enamel (An In-Vitro Study).Scientific reports · 2025Article
- Mathematical model capturing physicochemical and biological regulation of bone mineralization.Scientific reports · 2024Article
- Acidic Osteoid Templates the Plywood Structure of Bone Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Amelotin Promotes Mineralization and Adhesion in Collagen-Based Systems.Cellular and molecular bioengineering · 2022Article
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- Compositional and microhardness findings in tooth affected by X-linked hypophosphatemic rickets.Journal of clinical and experimental dentistry · 2020Article
- Non-Collagenous Dentin Protein Binding Sites Control Mineral Formation during the Biomineralisation Process in Radicular Dentin.Materials (Basel, Switzerland) · 2020Article
- The Significance and Utilisation of Biomimetic and Bioinspired Strategies in the Field of Biomedical Material Engineering: The Case of Calcium Phosphat-Protein Template Constructs.Materials (Basel, Switzerland) · 2020Review
- Recombinant human dentin matrix protein 1 (DMP1) induces the osteogenic differentiation of human periodontal ligament cells.Biotechnology reports (Amsterdam, Netherlands) · 2019Article
- Novel Insights into Regulation of Human Teeth Biomineralization: Deciphering the Role of Post-Translational Modifications in a Tooth Protein Extract.International journal of molecular sciences · 2019Article
- Characterization of protein extracts from different types of human teeth and insight in biomineralization.Scientific reports · 2019Article
- Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects.Journal of the mechanical behavior of biomedical materials · 2018Article
- Notch expressed by osteocytes plays a critical role in mineralisation.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Elevated solute transport at sites of diffuse matrix damage in cortical bone: Implications on bone repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ACP Nanoparticles Guided by Glycine.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Bone and dentin biomineralization are well-regulated processes mediated by extracellular matrix proteins. It is widely believed that specific matrix proteins in these tissues modulate nucleation of apatite nanoparticles and their growth into micrometer-sized crystals via molecular recognition at the protein-mineral interface. However, this assumption has been supported only circumstantially, and the exact mechanism remains unknown. Dentin matrix protein 1 (DMP1) is an acidic matrix protein, present in the mineralized matrix of bone and dentin. In this study, we have demonstrated using synchrotron small-angle X-ray scattering that DMP1 in solution can undergo oligomerization and temporarily stabilize the newly formed calcium phosphate nanoparticle precursors by sequestering them and preventing their further aggregation and precipitation. The solution structure represents the first low-resolution structural information for DMP1. Atomic force microscopy and transmission electron microscopy studies further confirmed that the nascent calcium phosphate nuclei formed in solution were assembled into ordered protein-mineral complexes with the aid of oligomerized DMP1, recombinant and native. This study reveals a novel mechanism by which DMP1 might facilitate initiation of mineral nucleation at specific sites during bone and dentin mineralization and prevent spontaneous calcium phosphate precipitation in areas in which mineralization is not desirable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.