ReviewPediatric nephrology (Berlin, Germany)2006
Ontogeny of drug elimination by the human kidney.
Review in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Incidence and risk factors of drug-induced kidney injury in children: a systematic review and meta-analysis.European journal of clinical pharmacology · 2023Pooled it
- Pharmacokinetics and Target Attainment of Antibiotics in Critically Ill Children: A Systematic Review of Current Literature.Clinical pharmacokinetics · 2020Pooled it
- Population pharmacokinetics of oseltamivir: pediatrics through geriatrics.Antimicrobial agents and chemotherapy · 2013Pooled it
- Population Pharmacokinetic Analysis of Enalapril and Enalaprilat in Newly Treated Children with Heart Failure: Implications for Safe Dosing of Enalapril (LENA Studies).Clinical pharmacokinetics · 2025Trial
- Is the recommended once-daily dose of lamivudine optimal in West African HIV-infected children?Antimicrobial agents and chemotherapy · 2010Trial
- Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children.British journal of clinical pharmacology · 2026Review
- Dosage Recommendations for Off-label Use of Mycophenolate Mofetil in Pediatric Patients with Thalassemia Undergoing Hematopoietic Stem Cell Transplantation: An Approach Based on Population Pharmacokinetic Studies.European journal of drug metabolism and pharmacokinetics · 2025Article
- Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study.BMC pediatrics · 2025Observational
- A closed-loop modular multiorgan-on-chips platform for self-sustaining and tightly controlled oxygenation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An evaluation of the empirical vancomycin dosing guide in pediatric cardiology.BMC pediatrics · 2024Article
- Population pharmacokinetics and dose rationale for aciclovir in term and pre-term neonates with herpes.Pharmacology research & perspectives · 2024Article
- Drug-associated kidney injury in children: a disproportionality analysis of the FDA Adverse Event Reporting System.European journal of pediatrics · 2023Article
- Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements.Pediatric nephrology (Berlin, Germany) · 2023Article
- Recent advances in the ontogeny of drug disposition.British journal of clinical pharmacology · 2022Review
- Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences for Optimal Dosing for Gram-Negative Infections: An Updated Review.Clinical pharmacokinetics · 2022Review
- A General Biphasic Bodyweight Model for Scaling Basal Metabolic Rate, Glomerular Filtration Rate, and Drug Clearance from Birth to Adulthood.The AAPS journal · 2022Article
- Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker.The AAPS journal · 2022Article
- Pharmacogenomics in Children.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Clinical Pharmacokinetics of Triazoles in Pediatric Patients.Clinical pharmacokinetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal clearance is an important route of drug elimination. While during the neonatal period there is minimal glomerular filtration and active tubular secretion of drugs, there is a well-described rapid development in these processes in the post-neonatal period. A less appreciated fact is that during toddlerhood, there is an "overshoot" of the glomerular filtration rate (GFR) well above the levels encountered in older children and adults, and there is an early achievement of adult levels in active drug secretion, which stays at a plateau throughout childhood and adulthood with an "overshoot" in toddlers due to specific transport mechanisms. This phenomenon leads to dose requirements for renally excreted drugs in this age group being, on a per-kilogram basis, much larger than in adults. This review discusses the mechanisms related to renal ontogeny in drug handling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.