ArticleImmunogenetics2005
Immunologic significance of HLA class I genes in measles virus-specific IFN-gamma and IL-4 cytokine immune responses.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Immunoinformatics-Based development of a Multi-Epitope vaccine candidate targeting coinfection by Klebsiella pneumoniae and Acinetobacter baumannii.BMC infectious diseases · 2025Article
- An overview of HLA variants in COVID-19 vaccine-induced autoimmunity.International journal of molecular epidemiology and genetics · 2025Review
- Vaccinomics: A scoping review.Vaccine · 2023Article
- Article
- Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents.Clinical immunology (Orlando, Fla.) · 2022Article
- Review
- The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study.Human vaccines & immunotherapeutics · 2017Article
- A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses.PloS one · 2017Article
- Article
- Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity.Human immunology · 2013Article
- The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.Expert review of vaccines · 2013Review
- HLA-DR specific monoclonal antibodies block lymphoproliferative response to measles vaccine in vitro: a pilot study.Vaccine · 2012Article
- Consistency of HLA associations between two independent measles vaccine cohorts: a replication study.Vaccine · 2012Article
- Article
- Associations between demographic variables and multiple measles-specific innate and cell-mediated immune responses after measles vaccination.Viral immunology · 2012Article
- Article
- Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.Omics : a journal of integrative biology · 2011Review
- Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine.The Journal of infectious diseases · 2011Article
- Optimizing high dimensional gene expression studies for immune response following smallpox vaccination using Taqman® low density immune arrays.Journal of immunological methods · 2011Article
- Differential cellular immune responses to wild-type and attenuated edmonston tag measles virus strains are primarily defined by the viral phosphoprotein gene.Journal of medical virology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The variability of immune responses modulated by human leukocyte antigen (HLA) genes and secreted cytokines is a significant factor in the development of a protective effect of measles vaccine. We studied the association between type 1 helper T cells (Th1)- and Th2-like cytokine immune responses and HLA class I alleles among 339 schoolchildren who previously received two doses of the measles vaccine. Median values for measles-specific interferon gamma (IFN-gamma) and interleukin-4 (IL-4) cytokines were 40.7 pg/ml [interquartile range (IQR) 8.1-176.7] and 9.7 pg/ml (IQR 2.8-24.3), respectively. Class I HLA-A (*0101 and *3101) and HLA-Cw (*0303 and *0501) alleles were significantly associated with measles-virus-induced IFN-gamma secretion. HLA-A*3101 and Cw*0303 were associated with a higher median IFN-gamma response, while A*0101 and Cw*0501 were associated with lower measles-specific IFN-gamma response. We found limited associations between HLA class I gene polymorphisms and Th2-like (IL-4) immune responses after measles vaccination, indicating that HLA class I molecules may have a limited effect on measles-vaccine-induced IL-4 secretion. Understanding the genetic factors that influence variations in cytokine secretion following measles vaccination will provide insight into the factors that influence both cell-mediated and humoral immunity to measles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.