ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2005
Engineered human dicentric chromosomes show centromere plasticity.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- The structure, function, and evolution of plant centromeres.Genome research · 2024Review
- Holocentromeres can consist of merely a few megabase-sized satellite arrays.Nature communications · 2023Article
- Plasticity in centromere organization and kinetochore composition: Lessons from diversity.Current opinion in cell biology · 2022Review
- Centromere deletion ineLife · 2020Article
- The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA.Nature communications · 2018Review
- Centromere inactivation on a neo-Y fusion chromosome in threespine stickleback fish.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement.Nucleic acids research · 2016Article
- The molecular basis for centromere identity and function.Nature reviews. Molecular cell biology · 2016Review
- Centromeres Off the Hook: Massive Changes in Centromere Size and Structure Following Duplication of CenH3 Gene in Fabeae Species.Molecular biology and evolution · 2015Article
- Atypical centromeres in plants-what they can tell us.Frontiers in plant science · 2015Review
- A new generation of human artificial chromosomes for functional genomics and gene therapy.Cellular and molecular life sciences : CMLS · 2013Review
- The evolutionary life cycle of the resilient centromere.Chromosoma · 2012Review
- Dicentric chromosomes: unique models to study centromere function and inactivation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Stretching the rules: monocentric chromosomes with multiple centromere domains.PLoS genetics · 2012Article
- Assembling pieces of the centromere epigenetics puzzle.Epigenetics · 2012Review
- Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.PLoS genetics · 2010Article
- Centromere activity in dicentric small supernumerary marker chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Identification of a maize neocentromere in an oat-maize addition line.Cytogenetic and genome research · 2009Article
- A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere.The EMBO journal · 2007Article
- Centromere Silencing Mechanisms.Progress in molecular and subcellular biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The centromere is essential for the faithful distribution of a cell's genetic material to subsequent generations. Despite intense scrutiny, the precise genetic and epigenetic basis for centromere function is still unknown. Here, we have used engineered dicentric human chromosomes to investigate mammalian centromere structure and function. We describe three classes of dicentric chromosomes isolated in different cell lines: functionally monocentric chromosomes, in which one of the two genetically identical centromeres is consistently inactivated; functionally dicentric chromosomes, in which both centromeres are consistently active; and dicentric chromosomes heterogeneous with respect to centromere activity. A study of serial single cell clones from heterogeneous cell lines revealed that while centromere activity is usually clonal, the centromere state (i.e. functionally monocentric or dicentric) in some lines can switch within a growing population of cells. Because pulsed field gel analysis indicated that the DNA at the centromeres of these chromosomes did not change detectably, this switching of the centromere state is most likely due to epigenetic changes. Inactivation of one of the two active centromeres in a functionally dicentric chromosome was observed in a percentage of cells after treatment with Trichostatin A, an inhibitor of histone deacetylation. This study provides evidence that the activity of human centromeres, while largely stable, can be subject to dynamic change, most likely due to epigenetic modification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.