ArticleProceedings of the National Academy of Sciences of the United States of America2005
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
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Who cites it
139 citing papers in PubMed.
- Protocol for high-sensitivity detection of microRNAs in adult Drosophila tissues using hybridization chain reaction.STAR protocols · 2026Article
- An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates.Genes & development · 2026Article
- Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague-Dawley rats and Beagle dogs.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- High-throughput microRNA sequencing in the developing branchial arches suggests miR-92b-3p regulation of a cardiovascular gene network.Frontiers in genetics · 2025Article
- A microRNA is the effector gene of a classic evolutionary hotspot locus.Science (New York, N.Y.) · 2024Article
- Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types.The EMBO journal · 2024Article
- A micro-RNA is the effector gene of a classic evolutionary hotspot locus.bioRxiv : the preprint server for biology · 2024Article
- A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.Nature communications · 2024Article
- Trials and Tribulations of MicroRNA Therapeutics.International journal of molecular sciences · 2024Review
- Circulating microRNAs as Potential Biomarkers in Pancreatic Cancer-Advances and Challenges.International journal of molecular sciences · 2023Review
- Stable Expression of dmiR-283 in the Brain Promises Positive Effects in Endurance Exercise on Sleep-Wake Behavior in AgingInternational journal of molecular sciences · 2023Article
- Article
- Comprehensive Identification of Human Cell Type Chromatin Activity-Specific and Cell Type Expression-Specific MicroRNAs.International journal of molecular sciences · 2022Article
- A transcriptomic atlas underlying developmental plasticity of seasonal forms of Bicyclus anynana butterflies.Molecular biology and evolution · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Resources and Methods for the Analysis of MicroRNA Function in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Discovery and functional understanding of MiRNAs in molluscs: a genome-wide profiling approach.RNA biology · 2021Article
- miR-184 delays cell proliferation, migration and invasion in prostate cancer by directly suppressing DLX1.Experimental and therapeutic medicine · 2021Article
- Single-cell visualization of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development.G3 (Bethesda, Md.) · 2021Article
- Why the hype - What are microRNAs and why do they provide unique investigative, diagnostic, and therapeutic opportunities in veterinary medicine?The Canadian veterinary journal = La revue veterinaire canadienne · 2020Review
79 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
MicroRNAs (miRNAs) are an extensive class of regulatory RNA whose specific functions in animals are generally unknown. Although computational methods have identified many potential targets of miRNAs, elucidating the spatial expression patterns of miRNAs is necessary to identify the sites of miRNA action. Here, we report the spatial patterns of miRNA transcription during Drosophila embryonic development, as revealed by in situ hybridization to nascent miRNA transcripts. We detect expression of 15 "stand-alone" miRNA loci and 9 intronic miRNA loci, which collectively represent 38 miRNA genes. We observe great variety in the spatial patterns of miRNA transcription, including preblastoderm stripes, in aspects of the central and peripheral nervous systems, and in cellular subsets of the mesoderm and endoderm. We also describe an intronic miRNA (miR-7) whose expression pattern is distinct from that of its host mRNA (bancal), which demonstrates that intronic miRNAs can be subject to independent cis-regulatory control. Intriguingly, the expression patterns of several fly miRNAs are analogous to those of their vertebrate counterparts, suggesting that these miRNAs may have ancient roles in animal patterning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.